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Bio-Design and Manufacturing  2021 Vol.4 No.4 P.491~501

10.1631/jzus.2003.0491


Correlation of matrix metalloproteinase-2, -9, tissue inhibitor-1 of matrix metalloproteinase and CD44 variant 6 in head and neck cancer metastasis


Author(s):  XU Ya-ping, ZHAO Xue-qun, SOMMER, K., MOUBAYED, P.

Affiliation(s):  The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   xuyap@yahoo.com

Key Words:  Head and neck cancer, Matrix metalloproteinase-2, -9 (MMP-2 and MMP-9), Tissue inhibitor-1 of matrix metalloproteinase (TIMP-1), Cell adhesion molecule 44 variant 6 (CD44 v6), HER2/neu, p53


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XU Ya-ping, ZHAO Xue-qun, SOMMER, K., MOUBAYED, P.. Correlation of matrix metalloproteinase-2, -9, tissue inhibitor-1 of matrix metalloproteinase and CD44 variant 6 in head and neck cancer metastasis[J]. Journal of Zhejiang University Science D, 2021, 4(4): 491~501.

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author="XU Ya-ping, ZHAO Xue-qun, SOMMER, K., MOUBAYED, P.",
journal="Journal of Zhejiang University Science D",
volume="4",
number="4",
pages="491~501",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2003.0491"
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%0 Journal Article
%T Correlation of matrix metalloproteinase-2, -9, tissue inhibitor-1 of matrix metalloproteinase and CD44 variant 6 in head and neck cancer metastasis
%A XU Ya-ping
%A ZHAO Xue-qun
%A SOMMER
%A K.
%A MOUBAYED
%A P.
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 4
%P 491~501
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2003.0491

TY - JOUR
T1 - Correlation of matrix metalloproteinase-2, -9, tissue inhibitor-1 of matrix metalloproteinase and CD44 variant 6 in head and neck cancer metastasis
A1 - XU Ya-ping
A1 - ZHAO Xue-qun
A1 - SOMMER
A1 - K.
A1 - MOUBAYED
A1 - P.
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 4
SP - 491
EP - 501
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2003.0491


Abstract: 
This study aimed to explore the molecular mechanism in tumor invasion and metastasis. The expression of matrix metalloproteinase-2,-9 (MMP-2, MMP-9), tissue inhibitor-1 of matrix metalloproteinase (TIMP-1), cell adhesion molecule 44 variant 6 (CD44v6), HER2/neu and p53 was investigated in 154 patients with head and neck squamous cell carcinoma (SCC) by ABC and ImmunoMax immunohistochemical method. Their clinical relevance and correlation were analysed. The expression of MMP-2, MMP-9, TIMP-1, CD44v6, HER2/neu and p53 was found in cancer cells in 87.01%, 85.71%, 68.18%, 98.05%, 55.19% and 50.65% cases respectively. Linear regression and correlation analysis revealed that there was close positive relationship (P<0.05) between the expression of MMP-2 and MMP-9, TIMP-1 and CD44v6, HER2/neu and MMP-9, MMP-2 and p53. Up-regulation of MMP-2 was accompanied by advanced T stage (P<0.01). There was also a trend of MMP-2 expression being related with tumor metastasis. Increased expression of HER2/neu was found in patients with tumor recurrence (P<0.05). The expression of TIMP-1 was higher in laryngeal cancer than that in pharyngeal cancer, and higher in keratinizing and non-keratinizing SCC than that in basaloid SCC (P<0.05). These findings suggested that MMP-2 and MMP-9, HER2/neu and MMP-9, MMP-2 and p53 had a coordinate function in aggression of tumor; that MMP-2 had a more important function than MMP-9 in tumor invasion and metastasis; and that HER2/neu might serve as a biomarker for poor prognosis in HNSCC.

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