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Received: 2004-06-01

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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.7 P.668~672

http://doi.org/10.1631/jzus.2005.B0668


Extracellular HIV Tat and Tat cysteine rich peptide increase CCR5 expression in monocytes


Author(s):  ZHENG Lin, YANG Yi-da, LU Guo-cai, SALVATO Maria S.

Affiliation(s):  Department of Infectious Diseases, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   yidayang@hotmail.com

Key Words:  HIV Tat, Tat cysteine rich peptide, CCR5, Monocytes


ZHENG Lin, YANG Yi-da, LU Guo-cai, SALVATO Maria S.. Extracellular HIV Tat and Tat cysteine rich peptide increase CCR5 expression in monocytes[J]. Journal of Zhejiang University Science B, 2005, 6(7): 668~672.

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author="ZHENG Lin, YANG Yi-da, LU Guo-cai, SALVATO Maria S.",
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publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2005.B0668"
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%A YANG Yi-da
%A LU Guo-cai
%A SALVATO Maria S.
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
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T1 - Extracellular HIV Tat and Tat cysteine rich peptide increase CCR5 expression in monocytes
A1 - ZHENG Lin
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A1 - LU Guo-cai
A1 - SALVATO Maria S.
J0 - Journal of Zhejiang University Science B
VL - 6
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SP - 668
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2005.B0668


Abstract: 
In our previous work we reported that HIV Tat and 6 cysteine rich peptides of Tat induce tumor necrosis factor-related apoptosis-induced ligand (TRAIL) in human monocytes (Yang et al., 2003). Here our results showed that HIV Tat and tat cysteine rich peptide increase CCR5 expression in human monocytes, and this activity is inhibited by rabbit anti-Tat. Boiled Tat does not increase CCR5 expression in monocytes. These results provide insight into a new mechanism by which HIV Tat plays a key role in the pathogenesis of HIV-1 infection.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

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<1>

Chintan@No address<thejamboy@yahoo.com>

2011-02-21 15:08:23

good work

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