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Received: 2005-11-18

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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.9 P.725-731


Carvedilol protected diabetic rat hearts via reducing oxidative stress

Author(s):  HUANG He, SHAN Jiang, PAN Xiao-hong, WANG Hui-ping, QIAN Ling-bo

Affiliation(s):  Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China; more

Corresponding email(s):   huanghell@163.com

Key Words:  Carvedilol, Diabetes, Oxidative stress, Bcl-2

HUANG He, SHAN Jiang, PAN Xiao-hong, WANG Hui-ping, QIAN Ling-bo. Carvedilol protected diabetic rat hearts via reducing oxidative stress[J]. Journal of Zhejiang University Science B, 2006, 7(9): 725-731.

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author="HUANG He, SHAN Jiang, PAN Xiao-hong, WANG Hui-ping, QIAN Ling-bo",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Carvedilol protected diabetic rat hearts via reducing oxidative stress
%A SHAN Jiang
%A PAN Xiao-hong
%A WANG Hui-ping
%A QIAN Ling-bo
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2006.B0725

T1 - Carvedilol protected diabetic rat hearts via reducing oxidative stress
A1 - SHAN Jiang
A1 - PAN Xiao-hong
A1 - WANG Hui-ping
A1 - QIAN Ling-bo
J0 - Journal of Zhejiang University Science B
VL - 7
IS - 9
SP - 725
EP - 731
%@ 1673-1581
Y1 - 2006
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2006.B0725

oxidative stress plays a dominant role in the pathogenesis of diabetes mellitus. bcl-2 gene has close connection with antioxidant stress destruction in many diseases including diabetes. carvedilol, an adrenoceptor blocker, also has antioxidant properties. To study the effect of carvedilol on the antioxidant status in diabetic hearts, we investigated carvedilol-administrated healthy and streptozotocin-induced diabetic rats. After small and large dosage carvedilol-administered for 5 weeks, hemodynamic parameters, the levels of malondialdehyde, activities of antioxidant enzymes and expression of bcl-2 mRNA in the cardiac tissues were measured. The diabetic rats not only had cardiac disfunction, weaker activities of antioxidant enzymes, but also showed lower expression of bcl-2. carvedilol treatment increased activities of antioxidant enzymes and expression of bcl-2 in healthy rats as well as diabetic rats. These results indicated that carvedilol partly improves cardiac function via its antioxidant properties in diabetic rats.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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