CLC number: R779.64
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Received: 2007-01-31
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CUI Hong-guang, LI Hui-yan. Effect of basic fibroblast growth factor (bFGF) on the treatment of exposure of the orbital implants[J]. Journal of Zhejiang University Science B, 2007, 8(9): 620-625.
@article{title="Effect of basic fibroblast growth factor (bFGF) on the treatment of exposure of the orbital implants",
author="CUI Hong-guang, LI Hui-yan",
journal="Journal of Zhejiang University Science B",
volume="8",
number="9",
pages="620-625",
year="2007",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2007.B0620"
}
%0 Journal Article
%T Effect of basic fibroblast growth factor (bFGF) on the treatment of exposure of the orbital implants
%A CUI Hong-guang
%A LI Hui-yan
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 9
%P 620-625
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0620
TY - JOUR
T1 - Effect of basic fibroblast growth factor (bFGF) on the treatment of exposure of the orbital implants
A1 - CUI Hong-guang
A1 - LI Hui-yan
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 9
SP - 620
EP - 625
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0620
Abstract: Objective: To evaluate the efficacy and the indication of basic fibroblast growth factor (bFGF) in the treatment of exposure of orbital implants. Design: Retrospective and observational case series. Methods: We reviewed 41 patients (41 eyes) suffering exposure of orbital implants from Jan. 2000 to June 2006. The study group patients with mild exposure received combined treatment with bFGF and antibiotic drops, and while the control group patients with mild exposure were treated with antibiotic drops only. The study group patients with moderate and severe exposure received combined treatment with bFGF and antibiotic drops, and after 2 months they were subjected to amniotic membrane transplantation, while the control group patients with moderate and severe exposure underwent amniotic membrane transplantation after using antibiotic drops. Observation of the growth of conjunctival epithelium and comparison of the healing rate of the two groups. Results: The healing rates of the mild, moderate and severe exposure study group were 100% and 92.3%. The healing rates of the mild, moderate and severe exposure control group were 55.6% and 66.7% respectively. The difference of the healing rates of the mild exposure study group and the control group was significant (P=0.033). And the difference of the healing rates of the moderate and severe exposure study group and the control group was not significant (P=0.167). Conclusion: bFGF may promote obviously the healing of orbital implant exposure, particularly it can be the first choice for the treatment of mild degree exposure. For the moderate and severe cases, it can be administered before surgical repair to enhance neovascularization and will tend to increase the success rate of surgical repair.
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