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Received: 2010-08-16

Revision Accepted: 2010-10-28

Crosschecked: 2010-11-08

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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.12 P.895-904


Improved myocardial perfusion and cardiac function by controlled-release basic fibroblast growth factor using fibrin glue in a canine infarct model

Author(s):  Shao-ping Nie, Xiao Wang, Shi-bin Qiao, Qiu-tang Zeng, Ju-quan Jiang, Xiao-qing Liu, Xiang-ming Zhu, Guo-xiang Cao, Chang-sheng Ma

Affiliation(s):  Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China, Union Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China

Corresponding email(s):   spnie@126.com

Key Words:  Angiogenesis, Basic fibroblast growth factor, Controlled release, Ischemic heart disease

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Shao-ping Nie, Xiao Wang, Shi-bin Qiao, Qiu-tang Zeng, Ju-quan Jiang, Xiao-qing Liu, Xiang-ming Zhu, Guo-xiang Cao, Chang-sheng Ma. Improved myocardial perfusion and cardiac function by controlled-release basic fibroblast growth factor using fibrin glue in a canine infarct model[J]. Journal of Zhejiang University Science B, 2010, 11(12): 895-904.

@article{title="Improved myocardial perfusion and cardiac function by controlled-release basic fibroblast growth factor using fibrin glue in a canine infarct model",
author="Shao-ping Nie, Xiao Wang, Shi-bin Qiao, Qiu-tang Zeng, Ju-quan Jiang, Xiao-qing Liu, Xiang-ming Zhu, Guo-xiang Cao, Chang-sheng Ma",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Improved myocardial perfusion and cardiac function by controlled-release basic fibroblast growth factor using fibrin glue in a canine infarct model
%A Shao-ping Nie
%A Xiao Wang
%A Shi-bin Qiao
%A Qiu-tang Zeng
%A Ju-quan Jiang
%A Xiao-qing Liu
%A Xiang-ming Zhu
%A Guo-xiang Cao
%A Chang-sheng Ma
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 12
%P 895-904
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000302

T1 - Improved myocardial perfusion and cardiac function by controlled-release basic fibroblast growth factor using fibrin glue in a canine infarct model
A1 - Shao-ping Nie
A1 - Xiao Wang
A1 - Shi-bin Qiao
A1 - Qiu-tang Zeng
A1 - Ju-quan Jiang
A1 - Xiao-qing Liu
A1 - Xiang-ming Zhu
A1 - Guo-xiang Cao
A1 - Chang-sheng Ma
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 12
SP - 895
EP - 904
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000302

Objective: Angiogenic therapy is emerging as a potential strategy for the treatment of ischemic heart disease but is limited by a relatively short half-life of growth factors. Fibrin glue (FG) provides a reservoir for controlled-release of growth factors. The aim of this study was to evaluate the effects of basic fibroblast growth factor (bFGF) incorporating FG on angiogenesis and cardiac performance in a canine infarct model. Methods: Acute myocardial infarction was induced by ligation of the left anterior descending coronary artery (LAD). Group I (n=6) underwent ligation of LAD alone. In Group II, transmural channels were created in the infarct area (n=6). In Group III, non-transmural channels were created to locate FG cylinders containing bFGF (n=6). Eight weeks after operation, myocardial perfusion was assessed by single photon emission computed tomography, cardiac function by echocardiography, and vascular development by immunohistochemical staining. Results: Total vascular density and the number of large vessels (internal diameter ≥50 μm) were dramatically higher in Group III than in Groups I and II at eight weeks. Only the controlled-release group exhibited an improvement in regional myocardial perfusion associated with lower defect score. Animals in Group III presented improved cardiac regional systolic and diastolic functions as well as global systolic function in comparison with the other two groups. Conclusions: Enhanced and sustained angiogenic response can be achieved by controlled-release bFGF incorporating FG within transmyocardial laser channels, thus enabling improvement in myocardial perfusion and cardiac function.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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