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CLC number: R54

On-line Access: 2010-03-29

Received: 2009-08-09

Revision Accepted: 2010-01-27

Crosschecked: 2010-03-10

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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.4 P.238-248


Growth factors induce the improved cardiac remodeling in autologous mesenchymal stem cell-implanted failing rat hearts

Author(s):  Ze-wei Tao, Long-gui Li, Zhao-hua Geng, Tao Dang, Shan-jun Zhu

Affiliation(s):  Department of Cardiovascular Diseases, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China

Corresponding email(s):   taozw@hotmail.com, lgli602@163.com

Key Words:  Mesenchymal stem cells, Growth factor, Myocardium, Cardiac remodeling

Ze-wei Tao, Long-gui Li, Zhao-hua Geng, Tao Dang, Shan-jun Zhu. Growth factors induce the improved cardiac remodeling in autologous mesenchymal stem cell-implanted failing rat hearts[J]. Journal of Zhejiang University Science B, 2010, 11(4): 238-248.

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author="Ze-wei Tao, Long-gui Li, Zhao-hua Geng, Tao Dang, Shan-jun Zhu",
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publisher="Zhejiang University Press & Springer",

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%T Growth factors induce the improved cardiac remodeling in autologous mesenchymal stem cell-implanted failing rat hearts
%A Ze-wei Tao
%A Long-gui Li
%A Zhao-hua Geng
%A Tao Dang
%A Shan-jun Zhu
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 4
%P 238-248
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0900244

T1 - Growth factors induce the improved cardiac remodeling in autologous mesenchymal stem cell-implanted failing rat hearts
A1 - Ze-wei Tao
A1 - Long-gui Li
A1 - Zhao-hua Geng
A1 - Tao Dang
A1 - Shan-jun Zhu
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 4
SP - 238
EP - 248
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0900244

Therapeutically delivered mesenchymal stem cells (MSCs) improve ventricular remodeling. However, the mechanism underlying MSC cardiac remodeling has not been clearly determined. Congestive heart failure (CHF) was induced in rats by cauterization of the left ventricular free wall. MSCs were cultured from autologous bone marrow and injected into the border zone and the remote myocardium 5 d after injury. Ten weeks later, when compared with sham operation, CHF significantly increased nucleus mitotic index, capillary density, and expression of insulin-like growth factor 1, hepatocyte growth factor and vascular endothelial growth factor in the border zone (P<0.01) and decreased each of them in the remote myocardium (P<0.05 or P<0.01). MSC implantation in CHF dramatically elevated expression of these growth factors in the remote myocardium and further elevated their expression in the border zone when compared with CHF without MSC addition (P<0.05 or P<0.01). This was paralleled by a higher nucleus mitotic index and a significantly increased capillary density both in the remote myocardium and in the border zone, and by a lower percentage of area of collagen and a higher percentage of area of myocardium in the border zone (P<0.05 or P<0.01), and cardiac remodeling markedly improved. Autologous MSC implantation promoted expression of growth factors in rat failing myocardium, which might enhance cardiomyogenesis and angiogenesis, and improved cardiac remodeling.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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