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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.9 P.647~660

10.1631/jzus.2007.B0647


Cell therapy in congestive heart failure


Author(s):  TAO Ze-wei, LI Long-gui

Affiliation(s):  Department of Cardiovascular Diseases, Xinqiao Hospital, the Third Military Medical University, Chongqing 400037, China

Corresponding email(s):   taozw@hotmail.com, lgli602@hotmail.com

Key Words:  Congestive heart failure, Acute myocardial infarction, Myocardial regeneration, Cell therapy


TAO Ze-wei, LI Long-gui. Cell therapy in congestive heart failure[J]. Journal of Zhejiang University Science B, 2007, 8(9): 647~660.

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author="TAO Ze-wei, LI Long-gui",
journal="Journal of Zhejiang University Science B",
volume="8",
number="9",
pages="647~660",
year="2007",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2007.B0647"
}

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%T Cell therapy in congestive heart failure
%A TAO Ze-wei
%A LI Long-gui
%J Journal of Zhejiang University SCIENCE B
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%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0647

TY - JOUR
T1 - Cell therapy in congestive heart failure
A1 - TAO Ze-wei
A1 - LI Long-gui
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 9
SP - 647
EP - 660
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0647


Abstract: 
congestive heart failure (CHF) has emerged as a major worldwide epidemic and its main causes seem to be the aging of the population and the survival of patients with post-myocardial infarction. Cardiomyocyte dropout (necrosis and apoptosis) plays a critical role in the progress of CHF; thus treatment of CHF by exogenous cell implantation will be a promising medical approach. In the acute phase of cardiac damage cardiac stem cells (CSCs) within the heart divide symmetrically and/or asymmetrically in response to the change of heart homeostasis, and at the same time homing of bone marrow stem cells (BMCs) to injured area is thought to occur, which not only reconstitutes CSC population to normal levels but also repairs the heart by differentiation into cardiac tissue. So far, basic studies by using potential sources such as BMCs and CSCs to treat animal CHF have shown improved ventricular remodelling and heart function. Recently, however, a few of randomized, double-blind, placebo-controlled clinical trials demonstrated mixed results in heart failure with BMC therapy during acute myocardial infarction.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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