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Journal of Zhejiang University SCIENCE B 2008 Vol.9 No.6 P.435-440

http://doi.org/10.1631/jzus.B0820051


Advanced primary peritoneal carcinoma: clinicopathological and prognostic factor analyses


Author(s):  Chao ZHANG, Xiao-ping LI, Heng CUI, Dan-hua SHEN, Li-hui WEI

Affiliation(s):  Gynecological Oncology Center, Peking University People’ more

Corresponding email(s):   xiaopingli@hotmail.com

Key Words:  Primary peritoneal carcinoma (PPC), Cytoreductive surgery, Chemotherapy, Immunohistochemistry, Prognosis


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Chao ZHANG, Xiao-ping LI, Heng CUI, Dan-hua SHEN, Li-hui WEI. Advanced primary peritoneal carcinoma: clinicopathological and prognostic factor analyses[J]. Journal of Zhejiang University Science B, 2008, 9(6): 435-440.

@article{title="Advanced primary peritoneal carcinoma: clinicopathological and prognostic factor analyses",
author="Chao ZHANG, Xiao-ping LI, Heng CUI, Dan-hua SHEN, Li-hui WEI",
journal="Journal of Zhejiang University Science B",
volume="9",
number="6",
pages="435-440",
year="2008",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B0820051"
}

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%T Advanced primary peritoneal carcinoma: clinicopathological and prognostic factor analyses
%A Chao ZHANG
%A Xiao-ping LI
%A Heng CUI
%A Dan-hua SHEN
%A Li-hui WEI
%J Journal of Zhejiang University SCIENCE B
%V 9
%N 6
%P 435-440
%@ 1673-1581
%D 2008
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820051

TY - JOUR
T1 - Advanced primary peritoneal carcinoma: clinicopathological and prognostic factor analyses
A1 - Chao ZHANG
A1 - Xiao-ping LI
A1 - Heng CUI
A1 - Dan-hua SHEN
A1 - Li-hui WEI
J0 - Journal of Zhejiang University Science B
VL - 9
IS - 6
SP - 435
EP - 440
%@ 1673-1581
Y1 - 2008
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820051


Abstract: 
Objective: To investigate the factors favoring a positive prognosis for advanced primary peritoneal carcinoma (PPC). Methods: Twenty-four cases meeting the criteria for PPC were analyzed retrospectively for the clinicopathologic profiles. immunohistochemistry was used to determine the expressions of p53, Top2α, Ki-67 and Her-2/neu. Then all these clinicopathological factors and molecular markers were correlated with the prognosis. Results: There were 15 cases of primary peritoneal serous papillary carcinoma (PPSPC), 6 cases of mixed epithelial carcinoma (MEC) and 3 cases of malignant mixed Mullerian tumor (MMMT). All patients underwent cytoreductive surgery with optimal debulking achieved in 3 cases. Among those receiving first-line chemotherapy, 13 patients received the TP regimen (paclitaxel-cisplatin or carboplatin) and 7 patients received the PAC regimen (cisplatin-doxorubicin-cyclophosphamide). The median overall survival of all patients was 42 months, while the breakdown for survival time for patients with PPSPC, MMT and MEC was 44, 13 and 19 months, respectively. The expressions of p53, Top2α and Ki-67 were all demonstrated in 11 cases respectively. None showed the expression of Her-2/neu. There were significant differences in the median survival between patients with PPSPC and those with MMMT (44 months vs 13 months, P<0.05), also between patients receiving TP combination and those receiving the PAC regimen (75 months vs 28 months, P<0.05). Another significant difference in the median progression-free survival (PFS) was identified between patients with positive p53 immunostaining and those with negative p53 immunostaining (15 months vs 47 months, P<0.05), whereas age, menopausal status, residual tumor size and the other molecular factors did not significantly impact survival. Conclusion: Patients with PPC should be treated with a comprehensive management plan including appropriate cytoreductive surgery and responsive chemotherapy. Overestimating an optimal debulking surgery may not benefit survival. The pathologic subtype, chemotherapy regimen and p53 overexpression were significant prognostic factors.

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