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Received: 2008-03-13

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Crosschecked: 2008-11-14

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Journal of Zhejiang University SCIENCE B 2008 Vol.9 No.12 P.990-995


L-Proline as an efficient and reusable promoter for the synthesis of coumarins in ionic liquid

Author(s):  Xiu-hong LIU, Ji-cai FAN, Yang LIU, Zhi-cai SHANG

Affiliation(s):  Department of Chemistry, Zhejiang University, Hangzhou 310027, China

Corresponding email(s):   shangzc@zju.edu.cn

Key Words:  L-Proline, Ionic liquid, Coumarins, Knoevenagel condensation

Xiu-hong LIU, Ji-cai FAN, Yang LIU, Zhi-cai SHANG. L-Proline as an efficient and reusable promoter for the synthesis of coumarins in ionic liquid[J]. Journal of Zhejiang University Science B, 2008, 9(12): 990-995.

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author="Xiu-hong LIU, Ji-cai FAN, Yang LIU, Zhi-cai SHANG",
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publisher="Zhejiang University Press & Springer",

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%T L-Proline as an efficient and reusable promoter for the synthesis of coumarins in ionic liquid
%A Xiu-hong LIU
%A Ji-cai FAN
%A Yang LIU
%A Zhi-cai SHANG
%J Journal of Zhejiang University SCIENCE B
%V 9
%N 12
%P 990-995
%@ 1673-1581
%D 2008
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820079

T1 - L-Proline as an efficient and reusable promoter for the synthesis of coumarins in ionic liquid
A1 - Xiu-hong LIU
A1 - Ji-cai FAN
A1 - Yang LIU
A1 - Zhi-cai SHANG
J0 - Journal of Zhejiang University Science B
VL - 9
IS - 12
SP - 990
EP - 995
%@ 1673-1581
Y1 - 2008
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820079

The effect of l-Proline as a promoter on the condensation reaction of salicylaldehyde or its derivatives with ethyl acetoacetate in neutral ionic liquid [emim]BF4 was studied. All reactions were carried out under mild reaction conditions and achieved high yields. Moreover, the ionic liquid containing l-Proline could be recycled and reused for several times without noticeably decreasing in productivity. The results show that the l-Proline-[emim]BF4 system has a potential in contribution to the development of environmentally friendly and inexpensive processes in organic syntheses.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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