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Journal of Zhejiang University SCIENCE B 2009 Vol.10 No.7 P.559-562


IgE myeloma with elevated level of serum CA125

Author(s):  Man-ling WANG, Qiang HUANG, Tian-xin YANG

Affiliation(s):  Department of Hematology, Zhejiang Provincial People’ more

Corresponding email(s):   wml12142002@yahoo.com

Key Words:  Immunoglobulin E (IgE), Multiple myeloma, Carbohydrate antigen 125 (CA125)

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Man-ling WANG, Qiang HUANG, Tian-xin YANG. IgE myeloma with elevated level of serum CA125[J]. Journal of Zhejiang University Science B, 2009, 10(7): 559-562.

@article{title="IgE myeloma with elevated level of serum CA125",
author="Man-ling WANG, Qiang HUANG, Tian-xin YANG",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T IgE myeloma with elevated level of serum CA125
%A Man-ling WANG
%A Qiang HUANG
%A Tian-xin YANG
%J Journal of Zhejiang University SCIENCE B
%V 10
%N 7
%P 559-562
%@ 1673-1581
%D 2009
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0820399

T1 - IgE myeloma with elevated level of serum CA125
A1 - Man-ling WANG
A1 - Qiang HUANG
A1 - Tian-xin YANG
J0 - Journal of Zhejiang University Science B
VL - 10
IS - 7
SP - 559
EP - 562
%@ 1673-1581
Y1 - 2009
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0820399

Objective: To explore clinical and laboratory features and significance of detecting serum carbohydrate antigen 125 (CA125) in immunoglobulin E (IgE) multiple myeloma. Methods: We reported the clinical findings of a male patient with IgE myeloma and elevated level of serum CA125 and reviewed the literature. Results: Laboratory tests of this patient on admission showed extremely high serum IgE and CA125, a bone marrow aspirate revealed abnormal plasma cells (38.4% of nucleated cells: 16.4% mature and 22% atypical), and in bone marrow biopsy, immunoperoxidase staining showed positive cytoplasmic staining for IgE and κ light chain within the vast majority of plasma cells. Computed tomography (CT) bone scans indicated wedge shape change and compressive fracture of thoracic vertebrae, and emission computed tomography (ECT) discovered multiple punctiform aggregation of radiation in both cervical ribs and spine. The serum IgE and CA125 gradually decreased to normal limits after eight cycles of chemotherapy. This patient is alive well with an 18-month complete remission. Conclusion: We reported the first case of IgE myeloma with elevated level of serum CA125. To further evaluate clinical characteristics and significance of CA125 in IgE myeloma, more cases are needed.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1] Alexander, R.L.Jr., Roodman, S.T., Petruska, P.J., Tsai, C.C., Janney, C.G., 1992. A new case of IgE myeloma. Clin. Chem., 38(11):2328-2332.

[2] de Rossi, G., de Sanctis, G., Bottari, V., Tribalto, M., Lopez, M., Petrucci, M.T., Fontana, L., 1987. Surface markers and cytotoxic activities of lymphocytes in monoclonal gammopathy of undetermined significance and untreated multiple myeloma. Increased phytohemagglutinin-induced cellular cytotoxicity and inverted helper/ suppressor cell ratio are features common to both diseases. Cancer Immunol. Immunother., 25(2):133-136.

[3] Dilek, I., Ayakta, H., Demir, C., Meral, C., Ozturk, M., 2005. CA125 levels in patients with non-Hodgkin lymphoma and other hematologic malignancies. Clin. Lab. Haematol., 27(1):51-55.

[4] Eagle, K., Ledemann, J., 1997. Tumor markers in ovarian malignancies. Oncology, 2(5):324-329.

[5] Gallango, M.L., Suinaga, R., Ramirez, M., 1988. IgE pyroglobulinemia in multiple myeloma. Clin. Chim. Acta, 176(2):151-156.

[6] Galton, D.A.G., Peto, R., 1973. Report on the first myelomatosis trial. Part 1. Analysis of presenting features of prognostic importance. Br. J. Haematol., 24(1):123-139.

[7] Jako, J.M., Gesztesi, T., Kaszas, I., 1997. IgE lamda monoclonal gammopathy and amyloidosis. Int. Arch. Allergy Immunol., 112(4):415-421.

[8] Johansson, S.G., Bennich, H., 1967. Immunological studies of an atypical (myeloma) immunoglobulin. Immunology, 13(4):381-394.

[9] Kairemo, K.J., Lindberg, M., Prytz, M., 1999. IgE myeloma: a case presentation and a review of the literature. Scand. J. Clin. Lab. Invest., 59(6):451-456.

[10] Kimura, J., Suzuki, N., Tomioka, H., Takahashi, H., 1981. A case of IgE myeloma. Rinsho. Ketsueki., 22(9): 1469-1477 (in Japanese).

[11] Koh, T., Ohno, T., Kageyama, S., Shimizu, N., Uchida, T., Tanaka, I., Kobayashi, T., Karitani, Y., Shirakawa, S., 1986. IgE multiple myeloma. A case report and review of the literature. Nippon. Ketsueki. Gakkai. Zasshi., 49(3): 696-702 (in Japanese).

[12] Lloyd, L., Klingberg, S.L., Kende, M., Howell, J.F., Clague, A.E., 2003. A case of IgE multiple myeloma. Pathology, 35(1):87-89.

[13] Ludwig, H., Vormittag, W., 1980. “Benign” monoclonal IgE gammopathy. BMJ, 281(6239):539-540.

[14] Russo, F., Lastoria, S., Svanera, G., Capobianco, G., de Chiara, A., Francia, R., Squame, E., de Martinis, F., Pinto, A., 2007. Long-term follow-up study on the role of serum CA-125 as a prognostic factor in 221 newly diagnosed patients with Hodgkin’s lymphoma. Leuk. Lymphoma, 48(4):723-730.

[15] San Miguel, J.F., Caballero, M.D., Gonzalez, M., 1985. T-cell subpopulations in patients with monoclonal gammopathies: essential monoclonal gammopathy, multiple myeloma, and Waldenstroms macroglobulinemia. Am. J. Hematol., 20(3):267-273.

[16] van Wijk, H.J., Kerckhaert, J.A., Oei, O.L., van Helden, H.P., 1986. Immunoglobulin E myeloma. Case report and review of the literature. Neth. J. Med., 29(6):196-200.

[17] Vladutiu, A.O., Kohli, R.K., Prezyna, A.P., 1976. Monoclonal IgE with renal failure. Am. J. Med., 61(6):957-962.

[18] Yoshitake, J., Hiramatsu, S., Komatsubara, Y., Matsubara, T., Fujita, T., 1976. A case of IgE myeloma. Acta Haematol. Jpn, 39(6):862-875 (in Japanese).

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