Full Text:   <2496>

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CLC number: R782.2

On-line Access: 2015-01-05

Received: 2014-07-08

Revision Accepted: 2014-10-23

Crosschecked: 2014-12-15

Cited: 2

Clicked: 4593

Citations:  Bibtex RefMan EndNote GB/T7714


Jiyeon KIM


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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.1 P.46-51


Growth effects of botulinum toxin type A injected unilaterally into the masseter muscle of developing rats

Author(s):  Chanyoung Park, Kitae Park, Jiyeon Kim

Affiliation(s):  Department of Pediatric Dentistry, Institute of Oral Health Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710, Korea; more

Corresponding email(s):   jychaee@pusan.ac.kr, jychaee@gmail.com

Key Words:  Botulinum toxin, Craniofacial growth, Mandible

Chanyoung Park, Kitae Park, Jiyeon Kim. Growth effects of botulinum toxin type A injected unilaterally into the masseter muscle of developing rats[J]. Journal of Zhejiang University Science B, 2015, 16(1): 46-51.

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author="Chanyoung Park, Kitae Park, Jiyeon Kim",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Growth effects of botulinum toxin type A injected unilaterally into the masseter muscle of developing rats
%A Chanyoung Park
%A Kitae Park
%A Jiyeon Kim
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 1
%P 46-51
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400192

T1 - Growth effects of botulinum toxin type A injected unilaterally into the masseter muscle of developing rats
A1 - Chanyoung Park
A1 - Kitae Park
A1 - Jiyeon Kim
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 1
SP - 46
EP - 51
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400192

Objective: To evaluate the effects of botulinum toxin type A (BTX-A) on mandible skeletal development by inducing muscle hypofunction. Methods: Four-week-old Sprague-Dawley rats (n=60) were divided into three groups: Group 1 animals served as controls and were injected with saline; Group 2 animals were injected unilaterally with BTX-A (the contralateral side was injected with saline); and Group 3 animals were injected bilaterally with BTX-A. In Group 2, the saline-injected side was designated the control side (Group 2-1), whereas the BTX-A-injected side was designated the experimental side (Group 2-2). After four weeks, the animals were sacrificed, dry skulls were prepared, and mandibles were measured. Results: In the unilateral group, the experimental side (Group 2-2) had reduced dimensions for all mandible measurements compared with the control side (Group 2-1), suggesting a local effect of BTX-A on mandible growth, likely due to muscle reduction. Conclusions: Localized BTX-A injection induced a change in craniofacial growth, and the skeletal effect was unilateral despite both sides of the mandible functioning as one unit.




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2016-03-08 04:27:36

Hi I'm dnwtristy student in CEU in Manila,Philippines I have passed 4 terms of dentristy I would like to know how can I transfer to zhejiayng university of dentristy?

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