Full Text:   <5038>

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CLC number: S82

On-line Access: 2015-06-08

Received: 2014-12-02

Revision Accepted: 2015-03-26

Crosschecked: 2015-05-13

Cited: 15

Clicked: 11089

Citations:  Bibtex RefMan EndNote GB/T7714


Xiang-hua Yan


Yang-fan Nie


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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.6 P.436-446


Cross-talk between bile acids and intestinal microbiota in host metabolism and health

Author(s):  Yang-fan Nie, Jun Hu, Xiang-hua Yan

Affiliation(s):  College of Animal Sciences and Technology, Huazhong Agricultural University, Wuhan 430070, China; more

Corresponding email(s):   xhyan@mail.hzau.edu.cn

Key Words:  Bile acid (BA), Farnesoid X receptor (FXR), Intestinal microbiota, Host metabolism, Autophagy

Yang-fan Nie, Jun Hu, Xiang-hua Yan. Cross-talk between bile acids and intestinal microbiota in host metabolism and health[J]. Journal of Zhejiang University Science B, 2015, 16(6): 436-446.

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author="Yang-fan Nie, Jun Hu, Xiang-hua Yan",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Cross-talk between bile acids and intestinal microbiota in host metabolism and health
%A Yang-fan Nie
%A Jun Hu
%A Xiang-hua Yan
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 6
%P 436-446
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400327

T1 - Cross-talk between bile acids and intestinal microbiota in host metabolism and health
A1 - Yang-fan Nie
A1 - Jun Hu
A1 - Xiang-hua Yan
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 6
SP - 436
EP - 446
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400327

bile acid (BA) is de novo synthesized exclusively in the liver and has direct or indirect antimicrobial effects. On the other hand, the composition and size of the BA pool can be altered by intestinal microbiota via the biotransformation of primary BAs to secondary BAs, and subsequently regulate the nuclear farnesoid X receptor (FXR; NR1H4). The BA-activated FXR plays important roles in BA synthesis and metabolism, glucose and lipid metabolism, and even hepatic autophagy. BAs can also play a role in the interplays among intestinal microbes. In this review, we mainly discuss the interactions between BAs and intestinal microbiota and their roles in regulating host metabolism, and probably the autophagic signaling pathway.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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