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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.10 P.781-792


Regulation of bile acid metabolism-related signaling pathways by gut microbiota in diseases

Author(s):  Er-Teng Jia, Zhi-Yu Liu, Min Pan, Jia-Feng Lu, Qin-Yu Ge

Affiliation(s):  State Key Laboratory of Bioelectronics, School of Biological Science & Medical Engineering, Southeast University, Nanjing 210096, China; more

Corresponding email(s):   geqinyu@seu.edu.cn

Key Words:  Gut microbiota, Bile acid, Farnesoid X receptor, Vitamin D receptor, Metabolism

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Er-Teng Jia, Zhi-Yu Liu, Min Pan, Jia-Feng Lu, Qin-Yu Ge. Regulation of bile acid metabolism-related signaling pathways by gut microbiota in diseases[J]. Journal of Zhejiang University Science B, 2019, 20(10): 781-792.

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journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Regulation of bile acid metabolism-related signaling pathways by gut microbiota in diseases
%A Er-Teng Jia
%A Zhi-Yu Liu
%A Min Pan
%A Jia-Feng Lu
%A Qin-Yu Ge
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900073

T1 - Regulation of bile acid metabolism-related signaling pathways by gut microbiota in diseases
A1 - Er-Teng Jia
A1 - Zhi-Yu Liu
A1 - Min Pan
A1 - Jia-Feng Lu
A1 - Qin-Yu Ge
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 10
SP - 781
EP - 792
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900073

Over the past decade, there has been increasing attention on the interaction between microbiota and bile acid metabolism. bile acids are not only involved in the metabolism of nutrients, but are also important in signal transduction for the regulation of host physiological activities. Microbial-regulated bile acid metabolism has been proven to affect many diseases, but there have not been many studies of disease regulation by microbial receptor signaling pathways. This review considers findings of recent research on the core roles of farnesoid X receptor (FXR), G protein-coupled bile acid receptor (TGR5), and vitamin D receptor (VDR) signaling pathways in microbial–host interactions in health and disease. Studying the relationship between these pathways can help us understand the pathogenesis of human diseases, and lead to new solutions for their treatments.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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