CLC number:
On-line Access: 2024-04-07
Received: 2023-01-31
Revision Accepted: 2023-07-29
Crosschecked: 2024-04-07
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Yulin GUO, Feng CAO, Fei LI. Impacts of pancreatic exocrine insufficiency on gut microbiota[J]. Journal of Zhejiang University Science B, 2024, 25(4): 271-279.
@article{title="Impacts of pancreatic exocrine insufficiency on gut microbiota",
author="Yulin GUO, Feng CAO, Fei LI",
journal="Journal of Zhejiang University Science B",
volume="25",
number="4",
pages="271-279",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300070"
}
%0 Journal Article
%T Impacts of pancreatic exocrine insufficiency on gut microbiota
%A Yulin GUO
%A Feng CAO
%A Fei LI
%J Journal of Zhejiang University SCIENCE B
%V 25
%N 4
%P 271-279
%@ 1673-1581
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300070
TY - JOUR
T1 - Impacts of pancreatic exocrine insufficiency on gut microbiota
A1 - Yulin GUO
A1 - Feng CAO
A1 - Fei LI
J0 - Journal of Zhejiang University Science B
VL - 25
IS - 4
SP - 271
EP - 279
%@ 1673-1581
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300070
Abstract: pancreatic exocrine insufficiency (PEI) can be induced by various kinds of diseases, including chronic pancreatitis, acute pancreatitis, and post-pancreatectomy. The main pathogenetic mechanism of PEI involves the decline of trypsin synthesis, disorder of pancreatic fluid flow, and imbalance of secretion feedback. Animal studies have shown that PEI could induce gut bacterial overgrowth and dysbiosis, with the abundance of Lactobacillus and Bifidobacterium increasing the most, which could be partially reversed by pancreatic enzyme replacement therapy. Clinical studies have also confirmed the association between PEI and the dysbiosis of gut microbiota. Pancreatic exocrine secretions and changes in duodenal pH as well as bile salt malabsorption brought about by PEI may affect and shape the abundance and composition of gut microbiota. In turn, the gut microbiota may impact the pancreatic exocrine acinus through potential bidirectional crosstalk. Going forward, more and higher-quality studies are needed that focus on the mechanism underlying the impact of PEI on the gut microbiota.
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