Full Text:   <304>

Summary:  <155>

CLC number: TP181

On-line Access: 2018-01-11

Received: 2017-06-08

Revision Accepted: 2017-11-19

Crosschecked: 2017-12-15

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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.1 P.25-37


Gene locations may contribute to predicting gene regulatory relationships

Author(s):  Jun Meng, Wen-Yuan Xu, Xiao Chen, Tao Lin, Xiao-Yu Deng

Affiliation(s):  Department of System Science and Engineering, School of Electrical Engineering, Zhejiang University, Hangzhou 310027, China; more

Corresponding email(s):   junmeng@zju.edu.cn

Key Words:  Prediction, Gene regulatory relationships, Order of gene location, Spatio-temporal neighborhood method, Zebrafish cardiogenesis

Jun Meng, Wen-Yuan Xu, Xiao Chen, Tao Lin, Xiao-Yu Deng. Gene locations may contribute to predicting gene regulatory relationships[J]. Journal of Zhejiang University Science B, 2018, 19(1): 25-37.

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author="Jun Meng, Wen-Yuan Xu, Xiao Chen, Tao Lin, Xiao-Yu Deng",
journal="Journal of Zhejiang University Science B",
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%0 Journal Article
%T Gene locations may contribute to predicting gene regulatory relationships
%A Jun Meng
%A Wen-Yuan Xu
%A Xiao Chen
%A Tao Lin
%A Xiao-Yu Deng
%J Journal of Zhejiang University SCIENCE B
%V 19
%N 1
%P 25-37
%@ 1673-1581
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700303

T1 - Gene locations may contribute to predicting gene regulatory relationships
A1 - Jun Meng
A1 - Wen-Yuan Xu
A1 - Xiao Chen
A1 - Tao Lin
A1 - Xiao-Yu Deng
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 1
SP - 25
EP - 37
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1700303

We propose that locations of genes on chromosomes can contribute to the prediction of gene regulatory relationships. We constructed a time-based gene regulatory network of zebrafish cardiogenesis on the basis of a spatio-temporal neighborhood method. Through the network, specific regulatory pathways and order of gene expression during zebrafish cardiogenesis were obtained. By comparing the order with locations of these genes on chromosomes, we discovered that there exists a reversal phenomenon between the order and order of gene locations. The discovery provides an inherent rule to instruct exploration of gene regulatory relationships. Specifically, the discovery can help to predict if regulatory relationships between genes exist and contribute to evaluating the correctness of discovered gene regulatory relationships.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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