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CLC number: TQ645; TS201.4

On-line Access: 2019-06-06

Received: 2019-01-21

Revision Accepted: 2019-03-24

Crosschecked: 2019-05-23

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.7 P.613-616

http://doi.org/10.1631/jzus.B1900018


Hypolipidemic activity of low-cholesterol ovum oil of Rana chensinensis and phytosterol (stigmasterol) in rats


Author(s):  Chang-Hui Zhao, Chao Zhao, Hai-Qing Ye, Chun-Yu Xi, Zheng-Ping Zou, Xin-Hui Zhou, Ping-Ping Hou, Tie-Hua Zhang

Affiliation(s):  College of Food Science and Engineering, Jilin University, Changchun 130062, China

Corresponding email(s):   zhangth@jlu.edu.cn

Key Words:  Ovum oil of Rana chensinensis, Forest frog, Hyperlipidemia


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Chang-Hui Zhao, Chao Zhao, Hai-Qing Ye, Chun-Yu Xi, Zheng-Ping Zou, Xin-Hui Zhou, Ping-Ping Hou, Tie-Hua Zhang. Hypolipidemic activity of low-cholesterol ovum oil of Rana chensinensis and phytosterol (stigmasterol) in rats[J]. Journal of Zhejiang University Science B, 2019, 20(7): 613-616.

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author="Chang-Hui Zhao, Chao Zhao, Hai-Qing Ye, Chun-Yu Xi, Zheng-Ping Zou, Xin-Hui Zhou, Ping-Ping Hou, Tie-Hua Zhang",
journal="Journal of Zhejiang University Science B",
volume="20",
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pages="613-616",
year="2019",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900018"
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A1 - Chun-Yu Xi
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A1 - Xin-Hui Zhou
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Abstract: 
The ovum oil of forest frog has various health beneficial functions. In the current research, we evaluated the hypolipidemic effects of the low-cholesterol ovum oil from the forest frog and its combination with stigmasterol in rats.

低胆固醇林蛙卵油和植物甾醇(豆甾醇)在大鼠中的降脂作用

目的:探索林蛙副产物林蛙卵油的开发价值.
创新点:首次验证了低胆固醇林蛙卵油的减重降脂功能.
方法:Sprague-Dawley大鼠连续被灌胃8周后,分成8组:(1)对照组喂食标准饲料;(2)高脂组喂食60%高脂饲料;(3)阳性对照组喂食3.33 mg/(kg·d)辛伐他汀;(4)OORC组喂食2 g/(kg·d)的低胆固醇林蛙卵油(OORC);(5)植物甾醇组喂食 0.48 g/(kg·d)的豆甾醇;(6)低剂量组喂食1 g/(kg·d)的低胆固醇OORC和0.24 g/(kg·d)的豆甾醇;(7)中剂量组喂食2 g/(kg·d)的低胆固醇OORC和0.48 g/(kg·d)的豆甾醇;(8)高剂量组喂食4 g/(kg·d)的低胆固醇OORC 和0.96 g/(kg·d)的豆甾醇.经过不同方法处理后,比较各组大鼠的体重、器官指数,以及血清中总胆固醇、甘油三酯、低密度脂蛋白和高密度脂蛋白浓度.同时,对动物肝脏进行组织切片染色并评价损伤情况.
结论:低胆固醇林蛙卵油或者其与植物甾醇(如豆甾醇)联用可以预防高脂饮食诱导的增重、肝损伤和高血脂症状.

关键词:林蛙卵油;林蛙;肥胖;高血脂

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

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[13]List of electronic supplementary materials

[14]Data S1 Materials and methods

[15]Table S1 Organ indices of the rats in different groups

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