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Marcos Roberto de Oliveira


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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.4 P.263-279


Effects of sulforaphane on brain mitochondria: mechanistic view and future directions

Author(s):  Fernanda Rafaela Jardim, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Marcos Roberto de Oliveira

Affiliation(s):  Forensic Institute, Forensic Toxicology Division, Postmortem Toxicology Sector, CEP 90160-093, Porto Alegre, RS, Brazil; more

Corresponding email(s):   mrobioq@gmail.com, mrobioq@yahoo.com.br

Key Words:  Sulforaphane, Brain, Mitochondria, Antioxidant, Nuclear factor erythroid 2-related factor 2 (Nrf2)

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Fernanda Rafaela Jardim, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Marcos Roberto de Oliveira. Effects of sulforaphane on brain mitochondria: mechanistic view and future directions[J]. Journal of Zhejiang University Science B, 2020, 21(4): 263-279.

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author="Fernanda Rafaela Jardim, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Marcos Roberto de Oliveira",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Effects of sulforaphane on brain mitochondria: mechanistic view and future directions
%A Fernanda Rafaela Jardim
%A Fhelipe Jolner Souza de Almeida
%A Matheus Dargesso Luckachaki
%A Marcos Roberto de Oliveira
%J Journal of Zhejiang University SCIENCE B
%V 21
%N 4
%P 263-279
%@ 1673-1581
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900614

T1 - Effects of sulforaphane on brain mitochondria: mechanistic view and future directions
A1 - Fernanda Rafaela Jardim
A1 - Fhelipe Jolner Souza de Almeida
A1 - Matheus Dargesso Luckachaki
A1 - Marcos Roberto de Oliveira
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 4
SP - 263
EP - 279
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900614

The organosulfur compound sulforaphane (SFN; C6H11NOS2) is a potent cytoprotective agent promoting antioxidant, anti-inflammatory, antiglycative, and antimicrobial effects in in vitro and in vivo experimental models. mitochondria are the major site of adenosine triphosphate (ATP) production due to the work of the oxidative phosphorylation (OXPHOS) system. They are also the main site of reactive oxygen species (ROS) production in nucleated human cells. mitochondrial impairment is central in several human diseases, including neurodegeneration and metabolic disorders. In this paper, we describe and discuss the effects and mechanisms of action by which SFN modulates mitochondrial function and dynamics in mammalian cells. mitochondria-related pro-apoptotic effects promoted by SFN in tumor cells are also discussed. SFN may be considered a cytoprotective agent, at least in part, because of the effects this organosulfur agent induces in mitochondria. Nonetheless, there are certain points that should be addressed in further experiments, indicated here as future directions, which may help researchers in this field of research.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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