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Marcos Roberto de Oliveira

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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.4 P.263-279

http://doi.org/10.1631/jzus.B1900614


Effects of sulforaphane on brain mitochondria: mechanistic view and future directions


Author(s):  Fernanda Rafaela Jardim, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Marcos Roberto de Oliveira

Affiliation(s):  Forensic Institute, Forensic Toxicology Division, Postmortem Toxicology Sector, CEP 90160-093, Porto Alegre, RS, Brazil; more

Corresponding email(s):   mrobioq@gmail.com, mrobioq@yahoo.com.br

Key Words:  Sulforaphane, Brain, Mitochondria, Antioxidant, Nuclear factor erythroid 2-related factor 2 (Nrf2)


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Fernanda Rafaela Jardim, Fhelipe Jolner Souza de Almeida, Matheus Dargesso Luckachaki, Marcos Roberto de Oliveira. Effects of sulforaphane on brain mitochondria: mechanistic view and future directions[J]. Journal of Zhejiang University Science B, 2020, 21(4): 263-279.

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journal="Journal of Zhejiang University Science B",
volume="21",
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pages="263-279",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1900614"
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%T Effects of sulforaphane on brain mitochondria: mechanistic view and future directions
%A Fernanda Rafaela Jardim
%A Fhelipe Jolner Souza de Almeida
%A Matheus Dargesso Luckachaki
%A Marcos Roberto de Oliveira
%J Journal of Zhejiang University SCIENCE B
%V 21
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900614

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T1 - Effects of sulforaphane on brain mitochondria: mechanistic view and future directions
A1 - Fernanda Rafaela Jardim
A1 - Fhelipe Jolner Souza de Almeida
A1 - Matheus Dargesso Luckachaki
A1 - Marcos Roberto de Oliveira
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 4
SP - 263
EP - 279
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900614


Abstract: 
The organosulfur compound sulforaphane (SFN; C6H11NOS2) is a potent cytoprotective agent promoting antioxidant, anti-inflammatory, antiglycative, and antimicrobial effects in in vitro and in vivo experimental models. mitochondria are the major site of adenosine triphosphate (ATP) production due to the work of the oxidative phosphorylation (OXPHOS) system. They are also the main site of reactive oxygen species (ROS) production in nucleated human cells. mitochondrial impairment is central in several human diseases, including neurodegeneration and metabolic disorders. In this paper, we describe and discuss the effects and mechanisms of action by which SFN modulates mitochondrial function and dynamics in mammalian cells. mitochondria-related pro-apoptotic effects promoted by SFN in tumor cells are also discussed. SFN may be considered a cytoprotective agent, at least in part, because of the effects this organosulfur agent induces in mitochondria. Nonetheless, there are certain points that should be addressed in further experiments, indicated here as future directions, which may help researchers in this field of research.

萝卜硫烷对脑线粒体的影响:机理观点和未来发展方向

概要:有机硫化物萝卜硫烷(SFN)是一种有效的细胞保护剂,在体外和体内实验模型中均可促进抗氧化、抗炎、抗糖化和抗菌作用.因为氧化磷酸化系统的存在,所以线粒体是三磷酸腺苷(ATP)的主要产生部位.同时,线粒体也是具核人体细胞中产生活性氧的主要场所.线粒体损伤在多种人类疾病中起着重要作用,包括神经退行性病变和代谢异常.本文描述和讨论了SFN调节哺乳动物细胞中线粒体功能和动力学的作用和机理,以及其对肿瘤细胞中线粒体促凋亡途径的促进作用.SFN对线粒体的调节作用使得它在一定程度上被认为是一种细胞保护剂.本文还指出了几个需要通过进一步实验解决的问题,即未来的可能研究方向,这可能会对该领域的研究人员具有指导作用.
关键词:萝卜硫素;脑;线粒体;抗氧化剂;Nrf2

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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