CLC number: R184
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2020-07-20
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Shao-Rui Hao, Ren Yan, Shan-Yan Zhang, Jiang-Shan Lian, Huan Cai, Xiao-Li Zhang, Lin Zheng, Hong-Yu Jia, Jian-Hua Hu, Guo-Dong Yu, Jue-Qing Gu, Chan-Yuan Ye, Ci-Liang Jin, Ying-Feng Lu, Jiao-Jiao Xin, Ji-Fang Sheng, Yi-Da Yang. Interferon-α2b spray inhalation did not shorten virus shedding time of SARS-CoV-2 in hospitalized patients: a preliminary matched case-control study[J]. Journal of Zhejiang University Science B, 2020, 21(8): 628-636.
@article{title="Interferon-α2b spray inhalation did not shorten virus shedding time of SARS-CoV-2 in hospitalized patients: a preliminary matched case-control study",
author="Shao-Rui Hao, Ren Yan, Shan-Yan Zhang, Jiang-Shan Lian, Huan Cai, Xiao-Li Zhang, Lin Zheng, Hong-Yu Jia, Jian-Hua Hu, Guo-Dong Yu, Jue-Qing Gu, Chan-Yuan Ye, Ci-Liang Jin, Ying-Feng Lu, Jiao-Jiao Xin, Ji-Fang Sheng, Yi-Da Yang",
journal="Journal of Zhejiang University Science B",
volume="21",
number="8",
pages="628-636",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000211"
}
%0 Journal Article
%T Interferon-α2b spray inhalation did not shorten virus shedding time of SARS-CoV-2 in hospitalized patients: a preliminary matched case-control study
%A Shao-Rui Hao
%A Ren Yan
%A Shan-Yan Zhang
%A Jiang-Shan Lian
%A Huan Cai
%A Xiao-Li Zhang
%A Lin Zheng
%A Hong-Yu Jia
%A Jian-Hua Hu
%A Guo-Dong Yu
%A Jue-Qing Gu
%A Chan-Yuan Ye
%A Ci-Liang Jin
%A Ying-Feng Lu
%A Jiao-Jiao Xin
%A Ji-Fang Sheng
%A Yi-Da Yang
%J Journal of Zhejiang University SCIENCE B
%V 21
%N 8
%P 628-636
%@ 1673-1581
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000211
TY - JOUR
T1 - Interferon-α2b spray inhalation did not shorten virus shedding time of SARS-CoV-2 in hospitalized patients: a preliminary matched case-control study
A1 - Shao-Rui Hao
A1 - Ren Yan
A1 - Shan-Yan Zhang
A1 - Jiang-Shan Lian
A1 - Huan Cai
A1 - Xiao-Li Zhang
A1 - Lin Zheng
A1 - Hong-Yu Jia
A1 - Jian-Hua Hu
A1 - Guo-Dong Yu
A1 - Jue-Qing Gu
A1 - Chan-Yuan Ye
A1 - Ci-Liang Jin
A1 - Ying-Feng Lu
A1 - Jiao-Jiao Xin
A1 - Ji-Fang Sheng
A1 - Yi-Da Yang
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 8
SP - 628
EP - 636
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000211
Abstract: Background: Currently, there are no drugs that have been proven to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Because of its broad antiviral activity, interferon (IFN) should be evaluated as a potential therapeutic agent for treatment of coronavirus disease 2019 (COVID-19), especially while COVID-19-specific therapies are still under development. Methods: Confirmed COVID-19 patients hospitalized in the First Affiliated Hospital, School of Medicine, Zhejiang University in Hangzhou, China, from January 19 to February 19, 2020 were enrolled in a retrospective study. The patients were separated into an IFN group and a control group according to whether they received initial IFN-α2b inhalation treatment after admission. Propensity-score matching was used to balance the confounding factors. Results: A total of 104 confirmed COVID-19 patients, 68 in the IFN group and 36 in the control group, were enrolled. Less hypertension (27.9% vs. 55.6%, P=0.006), dyspnea (8.8% vs. 25.0%, P=0.025), or diarrhea (4.4% vs. 19.4%, P=0.030) was observed in the IFN group. Lower levels of albumin and C-reactive protein and higher level of sodium were observed in the IFN group. Glucocorticoid dosage was lower in the IFN group (median, 40 vs. 80 mg/d, P=0.025). Compared to the control group, fewer patients in the IFN group were ventilated (13.2% vs. 33.3%, P=0.015) and admitted to intensive care unit (ICU) (16.2% vs. 44.4%, P=0.002). There were also fewer critical patients in the IFN group (7.4% vs. 25.0%, P=0.017) upon admission. Although complications during admission process were comparable between groups, the discharge rate (85.3% vs. 66.7%, P=0.027) was higher and the hospitalization time (16 vs. 21 d, P=0.015) was shorter in the IFN group. When other confounding factors were not considered, virus shedding time (10 vs. 13 d, P=0.014) was also shorter in the IFN group. However, when the influence of other factors was eliminated using propensity score matching, virus shedding time was not significantly shorter than that of the control group (12 vs. 15 d, P=0.206). Conclusions: IFN-α2b spray inhalation did not shorten virus shedding time of SARS-CoV-2 in hospitalized patients.
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