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Journal of Zhejiang University SCIENCE B 2021 Vol.22 No.4 P.310-317


Structural and physiological changes of the human body upon SARS-CoV-2 infection

Author(s):  Zhonglin WU, Qi ZHANG, Guo YE, Hui ZHANG, Boon Chin HENG, Yang FEI, Bing ZHAO, Jing ZHOU

Affiliation(s):  Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, Department of Orthopedic Surgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; more

Corresponding email(s):   zhoujing@zju.edu.cn

Key Words:  Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Coronavirus disease 2019 (COVID-19), Pathological change, Pathogenesis

Zhonglin WU, Qi ZHANG, Guo YE, Hui ZHANG, Boon Chin HENG, Yang FEI, Bing ZHAO, Jing ZHOU. Structural and physiological changes of the human body upon SARS-CoV-2 infection[J]. Journal of Zhejiang University Science B, 2021, 22(4): 310-317.

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author="Zhonglin WU, Qi ZHANG, Guo YE, Hui ZHANG, Boon Chin HENG, Yang FEI, Bing ZHAO, Jing ZHOU",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Structural and physiological changes of the human body upon SARS-CoV-2 infection
%A Zhonglin WU
%A Guo YE
%A Boon Chin HENG
%A Yang FEI
%A Bing ZHAO
%A Jing ZHOU
%J Journal of Zhejiang University SCIENCE B
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%P 310-317
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000523

T1 - Structural and physiological changes of the human body upon SARS-CoV-2 infection
A1 - Zhonglin WU
A1 - Guo YE
A1 - Hui ZHANG
A1 - Boon Chin HENG
A1 - Yang FEI
A1 - Bing ZHAO
A1 - Jing ZHOU
J0 - Journal of Zhejiang University Science B
VL - 22
IS - 4
SP - 310
EP - 317
%@ 1673-1581
Y1 - 2021
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2000523

Since December 2019, the novel coronavirus (severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)) has spread to many countries around the world, developing into a global pandemic with increasing numbers of deaths reported worldwide. To data, although some vaccines have been developed, there are no ideal drugs to treat novel coronavirus pneumonia (coronavirus disease 2019 (COVID-19)). By examining the structure of the coronavirus and briefly describing its possible pathogenesis based on recent autopsy reports conducted by various teams worldwide, this review analyzes the possible structural and functional changes of the human body upon infection with SARS-CoV-2. We observed that the most prominent pathological changes in COVID-19 patients are diffuse alveolar damage (DAD) of the lungs and microthrombus formation, resulting in an imbalance of the ventilation/perfusion ratio and respiratory failure. Although direct evidence of viral infection can also be found in other organs and tissues, the viral load is relatively small. The conclusion that the injuries of the extra-pulmonary organs are directly caused by the virus needs further investigation.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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