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On-line Access: 2022-02-17

Received: 2021-04-25

Revision Accepted: 2021-08-30

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Yin LI




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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.2 P.164-170


Chemerin promotes proliferation and migration of ovarian cancer cells by upregulating expression of PD-L1

Author(s):  Chenxi GAO, Jinming SHI, Jingxin ZHANG, Yin LI, Yi ZHANG

Affiliation(s):  Department of Gynecology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China; more

Corresponding email(s):   syzi@163.com, yinli@bjmu.edu.cn

Key Words:  Ovarian cancer, Intraperitoneal tumor microenvironment, Chemerin, Programmed death ligand 1 (PD-L1)

Chenxi GAO, Jinming SHI, Jingxin ZHANG, Yin LI, Yi ZHANG. Chemerin promotes proliferation and migration of ovarian cancer cells by upregulating expression of PD-L1[J]. Journal of Zhejiang University Science B, 2022, 23(2): 164-170.

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publisher="Zhejiang University Press & Springer",

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T1 - Chemerin promotes proliferation and migration of ovarian cancer cells by upregulating expression of PD-L1
A1 - Chenxi GAO
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2100392

ovarian cancer is the third-most-common malignant reproductive tumor in women. According to the American Cancer Society, it has the highest mortality rate of gynecological tumors. The five-year survival rate was only 29% during the period from 1975 to 2008 (Reid et al., 2017). In recent decades, the five-year survival rate of ovarian cancer has remained around 30% despite continuous improvements in surgery, chemotherapy, radiotherapy, and other therapeutic methods. However, because of the particularity of the volume and location of ovarian tissue, the early symptoms of ovarian cancer are hidden, and there is a lack of highly sensitive and specific screening methods. Most patients have advanced metastasis, including abdominal metastasis, when they are diagnosed (Reid et al., 2017). Therefore, exploring the mechanism of ovarian cancer metastasis and finding early preventive measures are key to improving the survival rate and reducing mortality caused by ovarian cancer.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1]AlkadyMM, Abdel-MesseihPL, NosseirNM, 2018. Assessment of serum levels of the adipocytokine chemerin in colorectal cancer patients. J Med Biochem, 37(3):313-319.

[2]BarbolinaMV, 2018. Molecular mechanisms regulating organ-specific metastases in epithelial ovarian carcinoma. Cancers (Basel), 10(11):444.

[3]ChangCH, QiuJ, O'SullivanD, et al., 2015. Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell, 162(6):1229-1241.

[4]ChiJY, WuZH, ChoiCHJ, et al., 2018. Three-dimensional adipose tissue imaging reveals regional variation in beige fat biogenesis and PRDM16-dependent sympathetic neurite density. Cell Metab, 27(1):226-236.e3.

[5]ClarkCA, GuptaHB, SareddyG, et al., 2016. Tumor-intrinsic PD-L1 signals regulate cell growth, pathogenesis, and autophagy in ovarian cancer and melanoma. Cancer Res, 76(23):6964-6974.

[6]DrakesML, StiffPJ, 2018. Regulation of ovarian cancer prognosis by immune cells in the tumor microenvironment. Cancers (Basel), 10(9):302.

[7]El-SagheerG, GayyedM, AhmadA, et al., 2018. Expression of chemerin correlates with a poor prognosis in female breast cancer patients. Breast Cancer (Dove Med Press), 10:169-176.

[8]FreemanGJ, LongAJ, IwaiY, et al., 2000. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med, 192(7):1027-1034.

[9]Garcia-DiazA, ShinDS, MorenoBH, et al., 2017. Interferon receptor signaling pathways regulating PD-L1 and PD-L2 expression. Cell Rep, 19(6):1189-1201.

[10]GhallabNA, ShakerOG, 2017. Serum and salivary levels of chemerin and MMP-9 in oral squamous cell carcinoma and oral premalignant lesions. Clin Oral Investig, 21(3):937-947.

[11]GhebehH, MohammedS, Al-OmairA, et al., 2006. The B7-H1 (PD-L1) T lymphocyte-inhibitory molecule is expressed in breast cancer patients with infiltrating ductal carcinoma: correlation with important high-risk prognostic factors. Neoplasia, 8(3):190-198.

[12]GoralskiKB, JacksonAE, McKeownBT, et al., 2019. More than an adipokine: the complex roles of chemerin signaling in cancer. Int J Mol Sci, 20(19):4778.

[13]HamanishiJ, MandaiM, IwasakiM, et al., 2007. Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer. Proc Natl Acad Sci USA, 104(9):3360-3365.

[14]HoY, WangSH, ChenYR, et al., 2019. Leptin-derived peptides block leptin-induced proliferation by reducing expression of pro-inflammatory genes in hepatocellular carcinoma cells. Food Chem Toxicol, 133:110808.

[15]HoffmannM, RakA, PtakA, 2018. Bisphenol A and its derivatives decrease expression of chemerin, which reverses its stimulatory action in ovarian cancer cells. Toxicol Lett, 291:61-69.

[16]IbrahimMM, 2010. Subcutaneous and visceral adipose tissue: structural and functional differences. Obes Rev, 11(1):11-18.

[17]IshikawaM, KitayamaJ, NagawaH, 2004. Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res, 10(13):4325-4331.

[18]KumarJD, KandolaS, TiszlaviczL, et al., 2016. The role of chemerin and ChemR23 in stimulating the invasion of squamous oesophageal cancer cells. Br J Cancer, 114(10):1152-1159.

[19]KumarJD, AolymatI, TiszlaviczL, et al., 2019. Chemerin acts via CMKLR1 and GPR1 to stimulate migration and invasion of gastric cancer cells: putative role of decreased TIMP-1 and TIMP-2. Oncotarget, 10(2):98-112.

[20]LiJJ, YinHK, GuanDX, et al., 2018. Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis. Br J Cancer, 118(10):1337-1348.

[21]MaineCJ, AzizNHA, ChatterjeeJ, et al., 2014. Programmed death ligand-1 over-expression correlates with malignancy and contributes to immune regulation in ovarian cancer. Cancer Immunol Immunother, 63(3):215-224.

[22]NiemanKM, KennyHA, PenickaCV, et al., 2011. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med, 17(11):1498-1503.

[23]PachynskiRK, ZabelBA, KohrtHE, et al., 2012. The chemoattractant chemerin suppresses melanoma by recruiting natural killer cell antitumor defenses. J Exp Med, 209(8):1427-1435.

[24]PagetS, 1889. The distribution of secondary growths in cancer of the breast. The Lancet, 133(3412):571-573.

[25]ReidBM, PermuthJB, SellersTA, 2017. Epidemiology of ovarian cancer: a review. Cancer Biol Med, 14(1):9-32.

[26]RennierK, ShinWJ, KrugE, et al., 2020. Chemerin reactivates PTEN and suppresses PD-L1 in tumor cells via modulation of a novel CMKLR1-mediated signaling cascade. Clin Cancer Res, 26(18):5019-5035.

[27]ReverchonM, CornuauM, RameC, et al., 2012. Chemerin inhibits IGF-1-induced progesterone and estradiol secretion in human granulosa cells. Hum Reprod, 27(6):1790-1800.

[28]ShinWJ, PachynskiRK, 2018. Chemerin modulation of tumor growth: potential clinical applications in cancer. Discov Med, 26(141):31-37.

[29]SteeleCB, ThomasCC, HenleySJ, et al., 2017. Vital signs: trends in incidence of cancers associated with overweight and obesity—United States, 2005‒2014. MMWR Morb Mortal Wkly Rep, 66(39):1052-1058.

[30]TreeckO, BuechlerC, OrtmannO, 2019. Chemerin and cancer. Int J Mol Sci, 20(15):3750.

[31]WangCH, WuWKK, LiuXD, et al., 2014. Increased serum chemerin level promotes cellular invasiveness in gastric cancer: a clinical and experimental study. Peptides, 51:131-138.

[32]WangZM, AguilarEG, LunaJI, et al., 2019. Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade. Nat Med, 25(1):141-151.

[33]WiseHM, HermidaMA, LeslieNR, 2017. Prostate cancer, PI3K, PTEN and prognosis. Clin Sci (Lond), 131(3):197-210.

[34]ZhangJ, JinHC, ZhuAK, et al., 2014. Prognostic significance of plasma chemerin levels in patients with gastric cancer. Peptides, 61:7-11.

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