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Received: 2021-06-10

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Jianhong ZHOU




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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.2 P.158-163


Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis

Author(s):  Jie LUO, Zhimin SONG, Tao ZHANG, Ketan CHU, Jingyi LI, Jianhong ZHOU, Jun LIN

Affiliation(s):  Department of Gynecology, Womens Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China; more

Corresponding email(s):   linjun@zju.edu.cn, zhoujh1117@zju.edu.cn

Key Words:  Ovarian endometriomas, Recurrence, Human telomerase reverse transcriptase, Ki-67, CA125

Jie LUO, Zhimin SONG, Tao ZHANG, Ketan CHU, Jingyi LI, Jianhong ZHOU, Jun LIN. Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis[J]. Journal of Zhejiang University Science B, 2022, 23(2): 158-163.

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journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis
%A Jie LUO
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%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100502

T1 - Upregulation of h-TERT and Ki-67 in ectopic endometrium is associated with recurrence of endometriosis
A1 - Jie LUO
A1 - Zhimin SONG
A1 - Tao ZHANG
A1 - Ketan CHU
A1 - Jingyi LI
A1 - Jianhong ZHOU
A1 - Jun LIN
J0 - Journal of Zhejiang University Science B
VL - 23
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SP - 158
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%@ 1673-1581
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2100502

At present, endometriosis remains a worldwide health burden, with the main symptoms of dysmenorrhea, chronic pelvic pain, and infertility, markedly reducing the quality of life (de Ziegler et al., 2010). Although there is no proof that the disease is associated with high mortality, this disorder can significantly contribute to the deterioration of women's general well-being (McPeak et al., 2018). The main current treatment for endometriosis is surgery to remove endometriotic lesions; however, the recurrence rate following surgical treatment is as high as 21.5% at two years and 40.0%‍–‍50.0% at five years post-surgery (Koga et al., 2015). To prevent recurrence, adjuvant treatment with drugs after surgery is recommended to prolong relapse-free intervals. However, it is inconvenient for patients to continuously use such medications in terms of adverse effects and cost (Turk, 2002).




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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