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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2300854


Ceria nanoparticles: biomedical applications and toxicity


Author(s):  Xiaoxuan FU, Peng LI, Xi CHEN, Yuanyuan MA, Rong WANG, Wenxuan JI, Jiakuo GU, Bowen SHENG, Yizhou WANG, Zhuhong ZHANG

Affiliation(s):  School of Pharmacy, Key Laboratory of Molecular Pharmacology and Drug Evaluation (Yantai University), Ministry of Education, Collaborative Innovation Center of Advanced Drug Delivery System and Biotech Drugs in Universities of Shandong, Yantai University, Yantai 264005, PR China; more

Corresponding email(s):   zhzhang0608@ytu.edu.cn, wangyizhou@zju.edu.cn

Key Words:  Ceria nanoparticles, Synthetic methods, Biomedical applications, Oxidative stress, Toxicity


Xiaoxuan FU, Peng LI, Xi CHEN, Yuanyuan MA, Rong WANG, Wenxuan JI, Jiakuo GU, Bowen SHENG, Yizhou WANG, Zhuhong ZHANG. Ceria nanoparticles: biomedical applications and toxicity[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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author="Xiaoxuan FU, Peng LI, Xi CHEN, Yuanyuan MA, Rong WANG, Wenxuan JI, Jiakuo GU, Bowen SHENG, Yizhou WANG, Zhuhong ZHANG",
journal="Journal of Zhejiang University Science B",
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pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300854"
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%T Ceria nanoparticles: biomedical applications and toxicity
%A Xiaoxuan FU
%A Peng LI
%A Xi CHEN
%A Yuanyuan MA
%A Rong WANG
%A Wenxuan JI
%A Jiakuo GU
%A Bowen SHENG
%A Yizhou WANG
%A Zhuhong ZHANG
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
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A1 - Xiaoxuan FU
A1 - Peng LI
A1 - Xi CHEN
A1 - Yuanyuan MA
A1 - Rong WANG
A1 - Wenxuan JI
A1 - Jiakuo GU
A1 - Bowen SHENG
A1 - Yizhou WANG
A1 - Zhuhong ZHANG
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
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Y1 - 1998
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2300854


Abstract: 
Cerium oxide nanoparticles (CeO2 NPs) have become popular materials in biomedical and industrial fields due to their potential applications in anti-oxidation, cancer therapy, photocatalytic degradation of pollutants, sensors, etc. Many methods, including gas phase, solid phase, liquid phase, and the newly proposed green synthesis method, have been reported for the synthesis of CeO2 NPs. Due to the wide application of CeO2 NPs, concerns about their adverse impacts on human health have been raised. This review covers recent studies on the biomedical applications of CeO2 NPs, including their use in the treatment of various diseases (e.g., Alzheimer’s disease, ischemic stroke, retinal damage, chronic inflammation, and cancer). CeO2 NP toxicity is discussed in terms of the different systems of the human body (e.g., cytotoxicity, genotoxicity, respiratory toxicity, neurotoxicity, and hepatotoxicity). This comprehensive review covers both fundamental discoveries and exploratory progress in CeO2 NP research that may lead to practical developments in the future.

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