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OX40L promotes follicular helper T cell differentiation and function in mice with immune thrombocytopenia
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Ziyin YANG, Lei HAI, Xiaoyu CHEN, Siwen WU, Yan LV, Dawei CUI, Jue XIE. OX40L promotes follicular helper T cell differentiation and function in mice with immune thrombocytopenia[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="OX40L promotes follicular helper T cell differentiation and function in mice with immune thrombocytopenia",
author="Ziyin YANG, Lei HAI, Xiaoyu CHEN, Siwen WU, Yan LV, Dawei CUI, Jue XIE",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300947"
}
%0 Journal Article
%T OX40L promotes follicular helper T cell differentiation and function in mice with immune thrombocytopenia
%A Ziyin YANG
%A Lei HAI
%A Xiaoyu CHEN
%A Siwen WU
%A Yan LV
%A Dawei CUI
%A Jue XIE
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300947
TY - JOUR
T1 - OX40L promotes follicular helper T cell differentiation and function in mice with immune thrombocytopenia
A1 - Ziyin YANG
A1 - Lei HAI
A1 - Xiaoyu CHEN
A1 - Siwen WU
A1 - Yan LV
A1 - Dawei CUI
A1 - Jue XIE
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300947
Abstract: immune thrombocytopenia (ITP) is a hemorrhagic autoimmune disease characterized by antibody-mediated platelet injury. ITP has complicated immunopathological mechanisms that need further elucidation. It is well known that the costimulatory molecules OX40L%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>OX40L and OX40 play essential roles in the immunological mechanisms of autoimmune diseases. Previously, we discovered that the expression of OX40L%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>OX40L and OX40 is significantly increased in the PBMCs of ITP patients. In our present study, OX40L%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>OX40L-induced Tfh cells exhibited an activated phenotype with elevated ICOS, PD-1, and CD40L expression in vitro. Moreover, aberrant OX40L%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>OX40L-OX40 expression might promote the Tfh1-to-Tfh2 shift in vivo, inducing the generation of autoantibodies by enhancing the helper function of Tfh cells for B lymphocytes in a mouse model, which might accelerate the progression of ITP. Additionally, signal transduction through the OX40L%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>OX40L-OX40 axis might be related to the activation of TRAF-NF-κB and JAK-STAT signaling pathways. Overall, OX40L%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>OX40L-OX40 signaling is proposed as a potential novel therapeutic target for ITP.
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