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On-line Access: 2022-12-17
Received: 2022-01-27
Revision Accepted: 2022-08-31
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Designs and methodologies to recreate in vitro human gut microbiota models
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Francesco Biagini, Costanza Daddi, Marco Calvigioni, Carmelo De Maria, Yu Shrike Zhang, Emilia Ghelardi & Giovanni Vozzi. Designs and methodologies to recreate in vitro human gut microbiota models[J]. Journal of Zhejiang University Science D, 2023, 6(3): 298-318.
@article{title="Designs and methodologies to recreate in vitro human gut microbiota models",
author="Francesco Biagini, Costanza Daddi, Marco Calvigioni, Carmelo De Maria, Yu Shrike Zhang, Emilia Ghelardi & Giovanni Vozzi",
journal="Journal of Zhejiang University Science D",
volume="6",
number="3",
pages="298-318",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-022-00210-6"
}
%0 Journal Article
%T Designs and methodologies to recreate in vitro human gut microbiota models
%A Francesco Biagini
%A Costanza Daddi
%A Marco Calvigioni
%A Carmelo De Maria
%A Yu Shrike Zhang
%A Emilia Ghelardi & Giovanni Vozzi
%J Journal of Zhejiang University SCIENCE D
%V 6
%N 3
%P 298-318
%@ 1869-1951
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-022-00210-6
TY - JOUR
T1 - Designs and methodologies to recreate in vitro human gut microbiota models
A1 - Francesco Biagini
A1 - Costanza Daddi
A1 - Marco Calvigioni
A1 - Carmelo De Maria
A1 - Yu Shrike Zhang
A1 - Emilia Ghelardi & Giovanni Vozzi
J0 - Journal of Zhejiang University Science D
VL - 6
IS - 3
SP - 298
EP - 318
%@ 1869-1951
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-022-00210-6
Abstract: The human gut microbiota is widely considered to be a metabolic organ hidden within our bodies, playing a crucial role in the host’s physiology. Several factors affect its composition, so a wide variety of microbes residing in the gut are present in the world population. Individual excessive imbalances in microbial composition are often associated with human disorders and pathologies, and new investigative strategies to gain insight into these pathologies and define pharmaceutical therapies for their treatment are needed. in vitro models of the human gut microbiota are commonly used to study microbial fermentation patterns, community composition, and host-microbe interactions. bioreactors and microfluidic devices have been designed to culture microorganisms from the human gut microbiota in a dynamic environment in the presence or absence of eukaryotic cells to interact with. In this review, we will describe the overall elements required to create a functioning, reproducible, and accurate in vitro culture of the human gut microbiota. In addition, we will analyze some of the devices currently used to study fermentation processes and relationships between the human gut microbiota and host eukaryotic cells.
Open peer comments: Debate/Discuss/Question/Opinion
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