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On-line Access: 2022-04-01
Received: 2022-11-10
Revision Accepted: 2022-02-20
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Evaluation of different crosslinking methods in altering the properties of extrusion-printed chitosan-based multi-material hydrogel composites
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Suihong Liu, Haiguang Zhang, Tilman Ahlfeld, David Kilian, Yakui Liu, Michael Gelinsky & Qingxi Hu. Evaluation of different crosslinking methods in altering the properties of extrusion-printed chitosan-based multi-material hydrogel composites[J]. Journal of Zhejiang University Science D, 2023, 6(2): 150-173.
@article{title="Evaluation of different crosslinking methods in altering the properties
of extrusion-printed chitosan-based multi-material hydrogel
composites",
author="Suihong Liu, Haiguang Zhang, Tilman Ahlfeld, David Kilian, Yakui Liu, Michael Gelinsky & Qingxi Hu",
journal="Journal of Zhejiang University Science D",
volume="6",
number="2",
pages="150-173",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-022-00194-3"
}
%0 Journal Article
%T Evaluation of different crosslinking methods in altering the properties
of extrusion-printed chitosan-based multi-material hydrogel
composites
%A Suihong Liu
%A Haiguang Zhang
%A Tilman Ahlfeld
%A David Kilian
%A Yakui Liu
%A Michael Gelinsky & Qingxi Hu
%J Journal of Zhejiang University SCIENCE D
%V 6
%N 2
%P 150-173
%@ 1869-1951
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-022-00194-3
TY - JOUR
T1 - Evaluation of different crosslinking methods in altering the properties
of extrusion-printed chitosan-based multi-material hydrogel
composites
A1 - Suihong Liu
A1 - Haiguang Zhang
A1 - Tilman Ahlfeld
A1 - David Kilian
A1 - Yakui Liu
A1 - Michael Gelinsky & Qingxi Hu
J0 - Journal of Zhejiang University Science D
VL - 6
IS - 2
SP - 150
EP - 173
%@ 1869-1951
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-022-00194-3
Abstract: Three-dimensional printing technologies exhibit tremendous potential in the advancing fields of tissue engineering and
regenerative medicine due to the precise spatial control over depositing the biomaterial. Despite their widespread utilization
and numerous advantages, the development of suitable novel biomaterials for extrusion-based 3D printing of scaffolds that
support cell attachment, proliferation, and vascularization remains a challenge. multi-material composite hydrogels present
incredible potential in this field. Thus, in this work, a multi-material composite hydrogel with a promising formulation
of chitosan/gelatin functionalized with egg white was developed, which provides good printability and shape fidelity. In
addition, a series of comparative analyses of different crosslinking agents and processes based on tripolyphosphate (TPP),
genipin (GP), and glutaraldehyde (GTA) were investigated and compared to select the ideal crosslinking strategy to enhance the
physicochemical and biological properties of the fabricated scaffolds. All of the results indicate that the composite hydrogel
and the resulting scaffolds utilizing TPP crosslinking have great potential in tissue engineering, especially for supporting
neo-vessel growth into the scaffold and promoting angiogenesis within engineered tissues.
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