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On-line Access: 2019-04-15

Received: 2018-09-12

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Bio-Design and Manufacturing  2018 Vol.1 No.4 P.245–253

10.1007/s42242-018-0024-z


Polycaprolactone–carboxymethyl cellulose composites for manufacturing porous scaffolds by material extrusion


Author(s):  M. E. Alemán-Domínguez, Z. Ortega, A. N. Benítez, Mario Monzón, L. V. Garzón, Sara Ajami, Chaozong Liu

Affiliation(s):  Departamento de Ingeniería de Procesos, Universidad de Las Palmas de Gran Canaria, Edificio de Fabricación integrada, Parque Científico-Tecnológico de la ULPGC, 35017 Las Palmas, Spain; more

Corresponding email(s):   mariaelena.aleman@ulpgc.es

Key Words:  Additive manufacturing, Tissue engineering, Viscosity model, Biomaterials, 3D printing, Bone regeneration


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M. E. Alemán-Domínguez, Z. Ortega, A. N. Benítez, Mario Monzón, L. V. Garzón, Sara Ajami, Chaozong Liu. Polycaprolactone–carboxymethyl cellulose composites for manufacturing porous scaffolds by material extrusion[J]. Journal of Zhejiang University Science D, 2018, 1(4): 245–253 .

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Abstract: 
Polycaprolactone–carboxymethyl cellulose composites have been obtained and used to print porous structures by material extrusion.Thematerialsusedcontained0,2and5%w/wofthecarboxymethylcelluloseadditive.Thesestructureshavebeen analyzed in terms of their morphology (including the evaluation of their porosity), mechanical properties under compression loadandcellaffinity.Cellaffinityhasbeenevaluatedbyculturingsheepmesenchymalstemcellsandanalyzingtheirviability bytheAlamarBlue® assayatdays1,3,6and8.Theresultsshowthatcompositessampleshavesimilarvaluesofporosityand apparent density than pure polycaprolactone ones. However, samples containing 5% w/w of carboxymethyl cellulose have micropores on the filaments due to a hindered deposition process. This characteristic affects the mechanical properties of the structures,sotheseoneshaveameancompressionmodulussignificantlylowerthanpurepolycaprolactonescaffolds.However, the samples containing 2% w/w of carboxymethyl cellulose show no significant difference with the pure polycaprolactone onesintermsoftheirmechanicalproperties.Moreover,thepresenceof2%w/wofadditiveimprovescellproliferationonthe surface of the porous structures. As complementary information, the flow properties of the composite materials were studied and the power law equations at 210 °C obtained, as this temperature was the 3D printing temperature. These equations can be useful for simulation and designing purposes of other manufacturing processes.

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