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Journal of Zhejiang University SCIENCE A 2005 Vol.6 No.7 P.640-642

http://doi.org/10.1631/jzus.2005.A0640


A new germacranolide from Carpesium cernuum


Author(s):  CAO Jian-xin, PAN Yuan-jiang, XU Chong-yang, HUANG Li-xia, MA Shu-hong, DAI Chang-liang, GAO Wan-wan

Affiliation(s):  Department of Chemistry, Zhejiang University, Hangzhou 310027, China; more

Corresponding email(s):   jxcao321@hotmail.com, panyuanjiang@zju.edu.cn

Key Words:  Carpesium cernuum, Compositae, Sesquiterpenoid, 2&alpha, , 3&beta, -dihydroxy-9-angeloxygermacra-4-en-6, 12-olide



Abstract: 
As a part of our interest in biologically active germacranolides from the genus Carpesium (compositae), we have investigated the constituents of %29&ck%5B%5D=abstract&ck%5B%5D=keyword'>%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>Carpesium cernuum. This paper reports the isolation and structural elucidation of a new germacranolide, cernolide A (Compound 1), from the herb. The structure of Compound 1 was determined as 2&alpha;,3&beta;-dihydroxy-9-angeloxygermacra-4-en-6,12-olide on the basis of spectral evidence. The skeleton of Compound 1 was elucidation by IR, MS, 1H and 13C NMR, COSY, HMQC and HMBC experiments. The stereochemistry of Compound 1 was deduced by ROESY spectral data. Finally, the procedures of extraction and isolation were described in detail.

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Ritesh@Phd student<riteshbiochem2006@gmail.com>

2010-12-03 15:28:52

Please provide me following article...

A new germacranolide from Carpesium cernuum

CAO Jian-xin, PAN Yuan-jiang, XU Chong-yang, HUANG Li-xia, MA Shu-hong, DAI Chang-liang, GAO Wan-wan

Department of Chemistry, Zhejiang University, Hangzhou 310027, China; Zhejiang Hisun Pharmaceutical Co., Ltd., Taizhou 318000, China

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