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Human placental mesenchymal stem cells and derived exosomes alleviate oxidative stress and ferroptosis via the Nrf2/GPX4 pathway in hemorrhagic shock-induced acute lung injury
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Shuai JIANG1,2,3, Qin ZHANG1,2, Ping WANG1,2, Mengxiao FENG1,2, Congying SONG1,2, Yuanqiang LU1,2. Human placental mesenchymal stem cells and derived exosomes alleviate oxidative stress and ferroptosis via the Nrf2/GPX4 pathway in hemorrhagic shock-induced acute lung injury[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Human placental mesenchymal stem cells and derived exosomes alleviate oxidative stress and ferroptosis via the Nrf2/GPX4 pathway in hemorrhagic shock-induced acute lung injury",
author="Shuai JIANG1,2,3, Qin ZHANG1,2, Ping WANG1,2, Mengxiao FENG1,2, Congying SONG1,2, Yuanqiang LU1,2",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2500470"
}
%0 Journal Article
%T Human placental mesenchymal stem cells and derived exosomes alleviate oxidative stress and ferroptosis via the Nrf2/GPX4 pathway in hemorrhagic shock-induced acute lung injury
%A Shuai JIANG1
%A 2
%A 3
%A Qin ZHANG1
%A 2
%A Ping WANG1
%A 2
%A Mengxiao FENG1
%A 2
%A Congying SONG1
%A 2
%A Yuanqiang LU1
%A 2
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2500470
TY - JOUR
T1 - Human placental mesenchymal stem cells and derived exosomes alleviate oxidative stress and ferroptosis via the Nrf2/GPX4 pathway in hemorrhagic shock-induced acute lung injury
A1 - Shuai JIANG1
A1 - 2
A1 - 3
A1 - Qin ZHANG1
A1 - 2
A1 - Ping WANG1
A1 - 2
A1 - Mengxiao FENG1
A1 - 2
A1 - Congying SONG1
A1 - 2
A1 - Yuanqiang LU1
A1 - 2
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2500470
Abstract: hemorrhagic shock (HS) induces acute lung injury (ALI) in the early phase. mesenchymal stem cells (MSCs) have shown potential in ameliorating HS-induced ALI; however, the mechanisms involved remain unclear. Our study investigated the therapeutic effects of human placental mesenchymal stem cells (hPMSCs) on HS-induced ALI and explored the underlying mechanisms. Male Sprague-Dawley (SD) rats were used to establish a model of HS, and the treatment group received injected hPMSCs. The biodistribution of hPMSCs in various organs of rats was imaged with the in vivo imaging system (IVIS) spectrum imaging system. The therapeutic effect and potential mechanisms for hPMSCs to improve HS-induced ALI were evaluated. The lungs and liver of HS rats were the main migration targets after hPMSCs transplantation. HPMSCs markedly mitigated lung pathological damage and diminished levels of reactive oxygen species (ROS), malondialdehyde (MDA), and Fe2+ in the lungs of HS rats, while also enhancing glutathione peroxidase 4 (GPX4) protein expression. exosomes derived from hPMSCs were taken up by rat alveolar type ࡱ epithelial (AT2) cells to inhibit ferroptosis by promoting overexpression of Nuclear factor erythroid 2-related factor 2 (Nrf2). Our study demonstrates the potential of hPMSC transplantation as a treatment for HS-induced ALI. The protective mechanism of hPMSCs for HS-induced ALI may include regulation of oxidative stress and ferroptosis.
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