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Received: 2007-01-04

Revision Accepted: 2007-03-14

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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.5 P.314-317


Assignment of CCR7 gene to chicken chromosome 27 by radiation hybrid panel mapping

Author(s):  TIAN Yong, LU Li-zhi, FU Yan, TAO Zheng-rong, SHEN Jun-da, WANG De-qian, YUAN Ai-ping, YIN Zhao-zheng

Affiliation(s):  Laboratory of Animal Genetics, College of Animal Sciences, Zhejiang University, Hangzhou 310029, China; more

Corresponding email(s):   yzhzh@zju.edu.cn

Key Words:  Radiation hybrid panel, Mapping, CCR7 gene, Chicken

TIAN Yong, LU Li-zhi, FU Yan, TAO Zheng-rong, SHEN Jun-da, WANG De-qian, YUAN Ai-ping, YIN Zhao-zheng. Assignment of CCR7 gene to chicken chromosome 27 by radiation hybrid panel mapping[J]. Journal of Zhejiang University Science B, 2007, 8(5): 314-317.

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author="TIAN Yong, LU Li-zhi, FU Yan, TAO Zheng-rong, SHEN Jun-da, WANG De-qian, YUAN Ai-ping, YIN Zhao-zheng",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Assignment of CCR7 gene to chicken chromosome 27 by radiation hybrid panel mapping
%A TIAN Yong
%A LU Li-zhi
%A FU Yan
%A TAO Zheng-rong
%A SHEN Jun-da
%A WANG De-qian
%A YUAN Ai-ping
%A YIN Zhao-zheng
%J Journal of Zhejiang University SCIENCE B
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%N 5
%P 314-317
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0314

T1 - Assignment of CCR7 gene to chicken chromosome 27 by radiation hybrid panel mapping
A1 - TIAN Yong
A1 - LU Li-zhi
A1 - FU Yan
A1 - TAO Zheng-rong
A1 - SHEN Jun-da
A1 - WANG De-qian
A1 - YUAN Ai-ping
A1 - YIN Zhao-zheng
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 5
SP - 314
EP - 317
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0314

The protein encoded by CC chemokine receptor 7 (CCR7) is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. To map the CCR7 gene in chicken chromosome, a 6 000 rads chicken-hamster radiation hybrid panel (ChickRH6) was used. PCR of samples from ChickRH6 revealed that the location of CCR7 gene is linked to the maker SEQ0347 (6 cR away) with LOD score of 16.6 and that the marker SEQ0347 is located on chromosome 27 at 27 cR of RH (radiation hydrid) map. We compared the corresponding human mRNA sequence with the predicted coding sequence of chicken CCR7 gene, and found that the assembled contig shared a high percentage of similarity with that of the human gene.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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