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On-line Access: 2012-09-04

Received: 2012-02-27

Revision Accepted: 2012-04-16

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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.9 P.731-744

http://doi.org/10.1631/jzus.B1200057


Efficacy and safety of rituximab therapy for systemic lupus erythematosus: a systematic review and meta-analysis


Author(s):  Lan Lan, Fei Han, Jiang-hua Chen

Affiliation(s):  Department of Kidney Disease Center, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   chenjianghua@zju.edu.cn

Key Words:  Systemic lupus erythematosus, Rituximab, Meta-analysis


Lan Lan, Fei Han, Jiang-hua Chen. Efficacy and safety of rituximab therapy for systemic lupus erythematosus: a systematic review and meta-analysis[J]. Journal of Zhejiang University Science B, 2012, 13(9): 731-744.

@article{title="Efficacy and safety of rituximab therapy for systemic lupus erythematosus: a systematic review and meta-analysis",
author="Lan Lan, Fei Han, Jiang-hua Chen",
journal="Journal of Zhejiang University Science B",
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number="9",
pages="731-744",
year="2012",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1200057"
}

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%T Efficacy and safety of rituximab therapy for systemic lupus erythematosus: a systematic review and meta-analysis
%A Lan Lan
%A Fei Han
%A Jiang-hua Chen
%J Journal of Zhejiang University SCIENCE B
%V 13
%N 9
%P 731-744
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1200057

TY - JOUR
T1 - Efficacy and safety of rituximab therapy for systemic lupus erythematosus: a systematic review and meta-analysis
A1 - Lan Lan
A1 - Fei Han
A1 - Jiang-hua Chen
J0 - Journal of Zhejiang University Science B
VL - 13
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SP - 731
EP - 744
%@ 1673-1581
Y1 - 2012
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1200057


Abstract: 
Objective: To review the efficacy and safety of rituximab therapy for systemic lupus erythematosus (SLE).Methods: We searched for randomized controlled trails and observational studies that evaluated the effect of rituximab based on the systemic lupus erythematosus disease activity index (SLEDAI), British Isles lupus assessment group index (BILAG), urine protein levels, and the prednisolone dose, and had adequate data to calculate the mean, standard deviation (SD), and 95% confidence intervals, and to systematically review and meta-analyze observational studies with fixed effects model or random effects model. Results: We included 2 randomized controlled studies and 19 observational clinical studies. We summarized the data from the 19 observational studies, analyzed the heterogeneity of the literature, and then used fixed effect model or random effect model for statistical analysis. The SLEDAI, BILAG, and urine protein levels and the prednisolone dosage were decreased after rituximab treatment, and the decreases in the BILAG, urine protein levels, and the prednisolone dose were found to be significant (P<0.05), when compared with baseline level. rituximab’s adverse effects generally could be controlled with an effective dosing regimen. Conclusions: Although there are still controversies about rituximab’s treatment on SLE, but our study had showed that rituximab had favorable effects on refractory lupus. The long-term efficacy and safety of rituximab require further study.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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