CLC number: R544.1
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2013-07-19
Cited: 2
Clicked: 6397
Yan Zhang, Xian-hui Qin, Jian-ping Li, Yi-min Cui, Ze-yuan Liu, Zhi-gang Zhao, Jun-bo Ge, De-ming Guan, Jian Hu, Yan-ni Wang, Fu-min Zhang, Xin Xu, Xi-ping Xu, Yong Huo. Factors underlying the association of body mass index with serum ALT in Chinese hypertensive adults without known hepatic diseases[J]. Journal of Zhejiang University Science B, 2013, 14(8): 743-748.
@article{title="Factors underlying the association of body mass index with serum ALT in Chinese hypertensive adults without known hepatic diseases",
author="Yan Zhang, Xian-hui Qin, Jian-ping Li, Yi-min Cui, Ze-yuan Liu, Zhi-gang Zhao, Jun-bo Ge, De-ming Guan, Jian Hu, Yan-ni Wang, Fu-min Zhang, Xin Xu, Xi-ping Xu, Yong Huo",
journal="Journal of Zhejiang University Science B",
volume="14",
number="8",
pages="743-748",
year="2013",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1200330"
}
%0 Journal Article
%T Factors underlying the association of body mass index with serum ALT in Chinese hypertensive adults without known hepatic diseases
%A Yan Zhang
%A Xian-hui Qin
%A Jian-ping Li
%A Yi-min Cui
%A Ze-yuan Liu
%A Zhi-gang Zhao
%A Jun-bo Ge
%A De-ming Guan
%A Jian Hu
%A Yan-ni Wang
%A Fu-min Zhang
%A Xin Xu
%A Xi-ping Xu
%A Yong Huo
%J Journal of Zhejiang University SCIENCE B
%V 14
%N 8
%P 743-748
%@ 1673-1581
%D 2013
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1200330
TY - JOUR
T1 - Factors underlying the association of body mass index with serum ALT in Chinese hypertensive adults without known hepatic diseases
A1 - Yan Zhang
A1 - Xian-hui Qin
A1 - Jian-ping Li
A1 - Yi-min Cui
A1 - Ze-yuan Liu
A1 - Zhi-gang Zhao
A1 - Jun-bo Ge
A1 - De-ming Guan
A1 - Jian Hu
A1 - Yan-ni Wang
A1 - Fu-min Zhang
A1 - Xin Xu
A1 - Xi-ping Xu
A1 - Yong Huo
J0 - Journal of Zhejiang University Science B
VL - 14
IS - 8
SP - 743
EP - 748
%@ 1673-1581
Y1 - 2013
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1200330
Abstract: Objective: High body mass index (BMI) is considered as the most important risk factor for elevated serum alanine aminotransferase (ALT) concentration. This study examined an array of factors, including waist circumference (WC) and folate deficiency, which may mediate the association of BMI with serum ALT concentration in Chinese hypertensive adults without known hepatic diseases. Methods: A multicenter, cross-sectional study was carried out. A total of 378 patients with mild or moderate hypertension and without known hepatic diseases were recruited from five hospitals in Harbin, Shanghai, Beijing, Xi’an, and Nanjing. Results: Of the 360 hypertensive patients with complete data in our final analysis, 13.6% had high ALT concentrations (>40 IU/L). Factors including BMI, WC, triglyceride level, and folate concentration were associated with ALT concentration in univariate analysis. Consistently higher prevalence rates of elevated ALT were observed in subjects with lower folate concentrations (≥12 vs. <12 nmol/L, 9.9% vs. 17.8%, P=0.03), with higher BMI (≥28 vs. <28 kg/m2, 21.5% vs. 11.4%, P=0.02) or higher WC (≥90 vs. <90 cm, 18.5% vs. 10.0%, P=0.02). However, in multivariate analysis, the association between BMI and ALT concentration disappeared (P=0.802 in males and 0.369 in females), while WC in females (P<0.001) and folate concentration (P=0.036 in males and 0.044 in females) remained as significant predictors for ALT concentration. Conclusions: This multicenter study demonstrated that WC and low folate concentration were important factors underlying the association between BMI and ALT concentrations in Chinese hypertensive adults without known hepatic diseases.
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