Full Text:
<2805>
Summary: 
<1972>
CLC number: R541.7+6
On-line Access: 2014-06-07
Received: 2014-02-09
Revision Accepted: 2014-05-06
Crosschecked: 2014-05-20
Cited: 4
Clicked: 4944
Is right ventricular mid-septal pacing superior to apical pacing in patients with high degree atrio-ventricular block and moderately depressed left ventricular function?
| ||||||||||||||
Kang Chen, Ye Mao, Shao-hua Liu, Qiong Wu, Qing-zhi Luo, Wen-qi Pan, Qi Jin, Ning Zhang, Tian-you Ling, Ying Chen, Gang Gu, Wei-feng Shen, Li-qun Wu. Is right ventricular mid-septal pacing superior to apical pacing in patients with high degree atrio-ventricular block and moderately depressed left ventricular function?[J]. Journal of Zhejiang University Science B, 2014, 15(6): 507-514.
@article{title="Is right ventricular mid-septal pacing superior to apical pacing in patients with high degree atrio-ventricular block and moderately depressed left ventricular function?",
author="Kang Chen, Ye Mao, Shao-hua Liu, Qiong Wu, Qing-zhi Luo, Wen-qi Pan, Qi Jin, Ning Zhang, Tian-you Ling, Ying Chen, Gang Gu, Wei-feng Shen, Li-qun Wu",
journal="Journal of Zhejiang University Science B",
volume="15",
number="6",
pages="507-514",
year="2014",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400034"
}
%0 Journal Article
%T Is right ventricular mid-septal pacing superior to apical pacing in patients with high degree atrio-ventricular block and moderately depressed left ventricular function?
%A Kang Chen
%A Ye Mao
%A Shao-hua Liu
%A Qiong Wu
%A Qing-zhi Luo
%A Wen-qi Pan
%A Qi Jin
%A Ning Zhang
%A Tian-you Ling
%A Ying Chen
%A Gang Gu
%A Wei-feng Shen
%A Li-qun Wu
%J Journal of Zhejiang University SCIENCE B
%V 15
%N 6
%P 507-514
%@ 1673-1581
%D 2014
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400034
TY - JOUR
T1 - Is right ventricular mid-septal pacing superior to apical pacing in patients with high degree atrio-ventricular block and moderately depressed left ventricular function?
A1 - Kang Chen
A1 - Ye Mao
A1 - Shao-hua Liu
A1 - Qiong Wu
A1 - Qing-zhi Luo
A1 - Wen-qi Pan
A1 - Qi Jin
A1 - Ning Zhang
A1 - Tian-you Ling
A1 - Ying Chen
A1 - Gang Gu
A1 - Wei-feng Shen
A1 - Li-qun Wu
J0 - Journal of Zhejiang University Science B
VL - 15
IS - 6
SP - 507
EP - 514
%@ 1673-1581
Y1 - 2014
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400034
Abstract: Objective: We are aimed to investigate whether right ventricular mid-septal pacing (RVMSP) is superior to conventional right ventricular apical pacing (RVAP) in improving clinical functional capacity and left ventricular ejection fraction (LVEF) for patients with high-degree atrio-ventricular block and moderately depressed left ventricle (LV) function. Methods: Ninety-two patients with high-degree atrio-ventricular block and moderately reduced LVEF (ranging from 35% to 50%) were randomly allocated to RVMSP (n=45) and RVAP (n=47). New York Heart Association (NYHA) functional class, echocardiographic LVEF, and distance during a 6-min walk test (6MWT) were determined at 18 months after pacemaker implantation. Serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) were measured using an enzyme-linked immunosorbent assay (ELISA) kit. Results: Compared with baseline, NYHA functional class remained unchanged at 18 months, distance during 6MWT (485 m vs. 517 m) and LVEF (36.7% vs. 41.8%) were increased, but BNP levels were reduced (2352 pg/ml vs. 710 pg/ml) in the RVMSP group compared with those in the RVAP group, especially in patients with LVEF 35%–40% (for all comparisons, P<0.05). However, clinical function capacity and LV function measurements were not significantly changed in patients with RVAP, despite the pacing measurements being similar in both groups, such as R-wave amplitude and capture threshold. Conclusions: RVMSP provides a better clinical utility, compared with RVAP, in patients with high-degree atrioventricular block and moderately depressed LV function whose LVEF levels ranged from 35% to 40%.
Open peer comments: Debate/Discuss/Question/Opinion
<1>