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CLC number: R657.5

On-line Access: 2015-05-04

Received: 2014-11-16

Revision Accepted: 2015-02-08

Crosschecked: 2015-04-09

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Hai-tao Zhu

http://orcid.org/0000-0003-0867-1354

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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.5 P.329-343

http://doi.org/10.1631/jzus.B1400310


Treatment of diabetes with encapsulated pig islets: an update on current developments


Author(s):  Hai-tao Zhu, Lu Lu, Xing-yu Liu, Liang Yu, Yi Lyu, Bo Wang

Affiliation(s):  Heart Center, Northwest Women’s and Children’s Hospital, Xi’an 710061, China; more

Corresponding email(s):   zht0915@163.com, bobwang75@yeah.net

Key Words:  Encapsulation, Pig, Islet, Xenotransplantation, Diabetes mellitus


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Hai-tao Zhu, Lu Lu, Xing-yu Liu, Liang Yu, Yi Lyu, Bo Wang. Treatment of diabetes with encapsulated pig islets: an update on current developments[J]. Journal of Zhejiang University Science B, 2015, 16(5): 329-343.

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pages="329-343",
year="2015",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400310"
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%A Hai-tao Zhu
%A Lu Lu
%A Xing-yu Liu
%A Liang Yu
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T1 - Treatment of diabetes with encapsulated pig islets: an update on current developments
A1 - Hai-tao Zhu
A1 - Lu Lu
A1 - Xing-yu Liu
A1 - Liang Yu
A1 - Yi Lyu
A1 - Bo Wang
J0 - Journal of Zhejiang University Science B
VL - 16
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SP - 329
EP - 343
%@ 1673-1581
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1400310


Abstract: 
The potential use of allogeneic islet transplantation in curing type 1 diabetes mellitus has been adequately demonstrated, but its large-scale application is limited by the short supply of donor islets and the need for sustained and heavy immunosuppressive therapy. encapsulation of pig islets was therefore suggested with a view to providing a possible alternative source of islet grafts and avoiding chronic immunosuppression and associated adverse or toxic effects. Nevertheless, several vital elements should be taken into account before this therapy becomes a clinical reality, including cell sources, encapsulation approaches, and implantation sites. This paper provides a comprehensive review of xenotransplantation of encapsulated pig islets for the treatment of type 1 diabetes mellitus, including current research findings and suggestions for future studies.

胶囊猪胰岛移植治疗糖尿病:现况与进展

概要:本文对胶囊猪胰岛异种移植治疗糖尿病的相关研究进行综述,展示目前的研究现状,指出目前存在的问题,并提出未来的研究方向。基于包被胰岛的体积、活性、功能及生物安全性等重要决定因素,对猪胰岛来源、胶囊包被技术/方法及植入部位的选择进行了对比性、系统性地阐述,具有较高的参考价值。胶囊猪胰岛异种移植治疗糖尿病具有良好的应用前景,小胶囊或保形包被技术或是今后的发展方向。
关键词:胶囊包被;猪;胰岛;异种移植;糖尿病

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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