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On-line Access: 2016-11-11

Received: 2016-06-28

Revision Accepted: 2016-09-17

Crosschecked: 2015-12-16

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Citations:  Bibtex RefMan EndNote GB/T7714


Min-hao Hu


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Journal of Zhejiang University SCIENCE B 2016 Vol.17 No.1 P.10-20


Impact of DNA mismatch repair system alterations on human fertility and related treatments

Author(s):  Min-hao HU, Shu-yuan LIU, Ning WANG, Yan WU, Fan JIN

Affiliation(s):  Key Laboratory of Reproductive Genetics (Zhejiang), Ministry of Education, and Centre of Reproductive Medicine, Womens Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China

Corresponding email(s):   jinfan@zju.edu.cn

Key Words:  DNA mismatch repair, Infertility, Assisted reproductive technology

Min-hao HU, Shu-yuan LIU, Ning WANG, Yan WU, Fan JIN. Impact of DNA mismatch repair system alterations on human fertility and related treatments[J]. Journal of Zhejiang University Science B, 2016, 17(1): 10-20.

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%T Impact of DNA mismatch repair system alterations on human fertility and related treatments
%A Min-hao HU
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%A Ning WANG
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T1 - Impact of DNA mismatch repair system alterations on human fertility and related treatments
A1 - Min-hao HU
A1 - Shu-yuan LIU
A1 - Ning WANG
A1 - Yan WU
A1 - Fan JIN
J0 - Journal of Zhejiang University Science B
VL - 17
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SP - 10
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1500162

DNA mismatch repair (MMR) is one of the biological pathways, which plays a critical role in DNA homeostasis, primarily by repairing base-pair mismatches and insertion/deletion loops that occur during DNA replication. MMR also takes part in other metabolic pathways and regulates cell cycle arrest. Defects in MMR are associated with genomic instability, predisposition to certain types of cancers and resistance to certain therapeutic drugs. Moreover, genetic and epigenetic alterations in the MMR system demonstrate a significant relationship with human fertility and related treatments, which helps us to understand the etiology and susceptibility of human infertility. Alterations in the MMR system may also influence the health of offspring conceived by assisted reproductive technology in humans. However, further studies are needed to explore the specific mechanisms by which the MMR system may affect human infertility. This review addresses the physiological mechanisms of the MMR system and associations between alterations of the MMR system and human fertility and related treatments, and potential effects on the next generation.


关 键 词:DNA错配修复;不孕;辅助生殖技术;后代


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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