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On-line Access: 2019-05-15

Received: 2019-03-24

Revision Accepted: 2019-04-03

Crosschecked: 2019-04-17

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Ling Li


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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.5 P.391-398


Role of SIRT1 in hematologic malignancies

Author(s):  Fei-teng Huang, Jie Sun, Lei Zhang, Xin He, Ying-hui Zhu, Hao-jie Dong, Han-ying Wang, Lei Zhu, Jing-ying Zou, Jin-wen Huang, Ling Li

Affiliation(s):  Department of Hematological Malignancies Translational Science, Gehr Family Center for Leukemia Research, Hematologic Malignancies and Stem Cell Transplantation Institute, Beckman Research Institute, City of Hope Medical Center, Duarte, CA 91010, USA; more

Corresponding email(s):   hemasrrsh@zju.edu.cn, lingli@coh.org

Key Words:  Sirtuin 1 (SIRT1), Hematologic malignancy, Stem cell, Drug resistance

Fei-teng Huang, Jie Sun, Lei Zhang, Xin He, Ying-hui Zhu, Hao-jie Dong, Han-ying Wang, Lei Zhu, Jing-ying Zou, Jin-wen Huang, Ling Li. Role of SIRT1 in hematologic malignancies[J]. Journal of Zhejiang University Science B, 2019, 20(5): 391-398.

@article{title="Role of SIRT1 in hematologic malignancies",
author="Fei-teng Huang, Jie Sun, Lei Zhang, Xin He, Ying-hui Zhu, Hao-jie Dong, Han-ying Wang, Lei Zhu, Jing-ying Zou, Jin-wen Huang, Ling Li",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Role of SIRT1 in hematologic malignancies
%A Fei-teng Huang
%A Jie Sun
%A Lei Zhang
%A Xin He
%A Ying-hui Zhu
%A Hao-jie Dong
%A Han-ying Wang
%A Lei Zhu
%A Jing-ying Zou
%A Jin-wen Huang
%A Ling Li
%J Journal of Zhejiang University SCIENCE B
%V 20
%N 5
%P 391-398
%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900148

T1 - Role of SIRT1 in hematologic malignancies
A1 - Fei-teng Huang
A1 - Jie Sun
A1 - Lei Zhang
A1 - Xin He
A1 - Ying-hui Zhu
A1 - Hao-jie Dong
A1 - Han-ying Wang
A1 - Lei Zhu
A1 - Jing-ying Zou
A1 - Jin-wen Huang
A1 - Ling Li
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 5
SP - 391
EP - 398
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900148

sirtuin 1 (SIRT1) is a protein deacetylase, which regulates various physiological activities by deacetylating different protein substrates. An increasing number of studies have revealed critical roles of SIRT1 in different aspects of cancers including metabolism, proliferation, genomic instability, and chemotherapy resistance. Depending on the protein targets in a certain oncogenic context, SIRT1 may play a unique role in each individual blood cancer subtype. Our previous work showed that activation of SIRT1 in primitive leukemia cells of acute myeloid leukemia (AML) and chronic myelogenous leukemia (CML) promotes disease maintenance. On the other hand, an SIRT1 agonist was shown to disrupt maintenance of myelodysplastic syndrome (MDS) stem cells and holds promise as a potential therapeutic approach. Herein, we present a concise summary of the different functions of SIRT1 in hematologic malignancies.


关键词:Sirtuin 1(SIRT1);血液系统肿瘤;干细胞;耐药

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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