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Huiyong ZHU


Yuwei DAI


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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.9 P.796-806


OCT4’s role and mechanism underlying oral squamous cell carcinoma

Author(s):  Yuwei DAI, Ziqiong WU, Yitong CHEN, Xinjian YE, Chaowei WANG, Huiyong ZHU

Affiliation(s):  Department of Oral and Maxillofacial Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; more

Corresponding email(s):   zhuhuiyong@zju.edu.cn

Key Words:  Cancer stem cell (CSC), Octamer-binding transcription factor 4 (OCT4), Oral squamous cell carcinoma (OSCC), Prognosis, Signaling pathway

Yuwei DAI, Ziqiong WU, Yitong CHEN, Xinjian YE, Chaowei WANG, Huiyong ZHU. OCT4’s role and mechanism underlying oral squamous cell carcinoma[J]. Journal of Zhejiang University Science B, 2023, 24(9): 796-806.

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author="Yuwei DAI, Ziqiong WU, Yitong CHEN, Xinjian YE, Chaowei WANG, Huiyong ZHU",
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publisher="Zhejiang University Press & Springer",

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%T OCT4’s role and mechanism underlying oral squamous cell carcinoma
%A Yuwei DAI
%A Ziqiong WU
%A Yitong CHEN
%A Xinjian YE
%A Chaowei WANG
%A Huiyong ZHU
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200602

T1 - OCT4’s role and mechanism underlying oral squamous cell carcinoma
A1 - Yuwei DAI
A1 - Ziqiong WU
A1 - Yitong CHEN
A1 - Xinjian YE
A1 - Chaowei WANG
A1 - Huiyong ZHU
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 9
SP - 796
EP - 806
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200602

oral squamous cell carcinoma (OSCC), a common malignancy of the head and neck, ranks sixth worldwide in terms of cancers with the most negative impact, owing to tumor relapse rates, cervical lymphnode metastasis, and the lack of an efficacious systemic therapy. Its prognosis is poor, and its mortality rate is high. octamer-binding transcription factor 4 (OCT4) is a member of the Pit-Oct-Unc (POU) family and is a key reprogramming factor that produces a marked effect in preserving the pluripotency and self-renewal state of embryonic stem cells (ESCs). According to recent studies, OCT4 participates in retaining the survival of OSCC cancer stem cells (CSCs), which has far-reaching implications for the occurrence, recurrence, metastasis, and prognosis of oral carcinogenesis. Therefore, we summarize the structure, subtypes, and function of OCT4 as well as its role in the occurrence, progression, and prognosis of OSCC.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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