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Received: 2019-03-29

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Su-dan He


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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.5 P.399-413


Complex roles of necroptosis in cancer

Author(s):  Fang Zhu, Wei Zhang, Tao Yang, Su-dan He

Affiliation(s):  Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Soochow University, Suzhou 215123, China; more

Corresponding email(s):   hesudan2018@163.com

Key Words:  Cell death, Necroptosis, Cancer, Mixed lineage kinase domain-like protein (MLKL), Receptor-interacting protein (RIP) kinase

Fang Zhu, Wei Zhang, Tao Yang, Su-dan He. Complex roles of necroptosis in cancer[J]. Journal of Zhejiang University Science B, 2019, 20(5): 399-413.

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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1900160

necroptosis is a tightly regulated form of necrosis that requires the activation of receptor-interacting protein (RIP) kinases RIPK1 and RIPK3, as well as the RIPK3 substrate mixed lineage kinase domain-like protein (MLKL). Because of membrane rupture, necroptotic cells release damage-associated molecular patterns (DAMPs) that evoke immune responses. necroptosis is emerging as an important cellular response in the modulation of cancer initiation, progression, and metastasis. necroptosis of cancer cells is considered to be an immunogenic cell death capable of activating anti-tumor immunity. necroptosis also participates in the promotion of myeloid cell-induced adaptive immune suppression and thus contributes to oncogenesis. In addition, necroptosis of endothelial cells and tumor cells is conducive to tumor metastasis. In this review, we summarize the current knowledge of the complex role of necroptosis in cancer and discuss the potential of targeting necroptosis components for cancer therapies.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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