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On-line Access: 2021-09-25
Received: 2020-11-12
Revision Accepted: 2021-06-19
Crosschecked: 2021-09-25
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Coaxial bioprinted microfibers with mesenchymal stem cells for glioma microenvironment simulation
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Zhizhong Jin, Xinda Li, Boxun Liu, Xinru Yan, Shuai Han, Tao Xu & Anhua Wu . Coaxial bioprinted microfibers with mesenchymal stem cells for glioma microenvironment simulation[J]. Journal of Zhejiang University Science D, 2022, 5(2): 348-357.
@article{title="Coaxial bioprinted microfibers with mesenchymal stem cells for glioma microenvironment simulation",
author="Zhizhong Jin, Xinda Li, Boxun Liu, Xinru Yan, Shuai Han, Tao Xu & Anhua Wu ",
journal="Journal of Zhejiang University Science D",
volume="5",
number="2",
pages="348-357",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00155-2"
}
%0 Journal Article
%T Coaxial bioprinted microfibers with mesenchymal stem cells for glioma microenvironment simulation
%A Zhizhong Jin
%A Xinda Li
%A Boxun Liu
%A Xinru Yan
%A Shuai Han
%A Tao Xu & Anhua Wu
%J Journal of Zhejiang University SCIENCE D
%V 5
%N 2
%P 348-357
%@ 1869-1951
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00155-2
TY - JOUR
T1 - Coaxial bioprinted microfibers with mesenchymal stem cells for glioma microenvironment simulation
A1 - Zhizhong Jin
A1 - Xinda Li
A1 - Boxun Liu
A1 - Xinru Yan
A1 - Shuai Han
A1 - Tao Xu & Anhua Wu
J0 - Journal of Zhejiang University Science D
VL - 5
IS - 2
SP - 348
EP - 357
%@ 1869-1951
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00155-2
Abstract: Due to their special anatomical and physiological features, central nervous system diseases still presented challenges, despite the fact that some advances have been made in early diagnosis and precision medicine. One of the complexities in treating tumors is the tumor microenvironment, which includes mesenchymal stem cells (MSCs) that exhibit tumor tropism and can be used for cell therapy. However, whether MSCs promote or suppress gliomas is still unclear, especially in glioma microenvironments. In this study, a coaxial microfiber was designed to mimic the tumor microenvironment and to reveal the effect of MSCs on glioma cells. The fiber shell was composed of MSCs and alginate, and the core was filled with U87MG (glioblastoma) cells and gelatin methacrylate. This Shell-MSC/Core-U87MG microenvironment improved the proliferation, survival, invasion, metastasis, and drug resistance of glioma cells, while simultaneously maintaining the stemness of glioma cells. In summary, coaxial extrusion bioprinted Shell-MSC/Core-U87MG microfiber is an ideal platform for tumor and stromal cell coculture to observe tumor biological behavior in vitro.
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