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On-line Access: 2017-09-05

Received: 2016-07-25

Revision Accepted: 2016-11-22

Crosschecked: 2017-08-16

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Bing-yu Xiang


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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.9 P.737-746


Mesenchymal stem cells as therapeutic agents and in gene delivery for the treatment of glioma

Author(s):  Bing-yu Xiang, Lu Chen, Xiao-jun Wang, Charlie Xiang

Affiliation(s):  State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, and Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s):   cxiang@zju.edu.cn

Key Words:  Cancer, Glioma, Mesenchymal stem cells, Stem cells, Therapy

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Bing-yu Xiang, Lu Chen, Xiao-jun Wang, Charlie Xiang. Mesenchymal stem cells as therapeutic agents and in gene delivery for the treatment of glioma[J]. Journal of Zhejiang University Science B, 2017, 18(9): 737-746.

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%T Mesenchymal stem cells as therapeutic agents and in gene delivery for the treatment of glioma
%A Bing-yu Xiang
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%A Xiao-jun Wang
%A Charlie Xiang
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600337

T1 - Mesenchymal stem cells as therapeutic agents and in gene delivery for the treatment of glioma
A1 - Bing-yu Xiang
A1 - Lu Chen
A1 - Xiao-jun Wang
A1 - Charlie Xiang
J0 - Journal of Zhejiang University Science B
VL - 18
IS - 9
SP - 737
EP - 746
%@ 1673-1581
Y1 - 2017
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600337

stem cells%29&ck%5B%5D=abstract&ck%5B%5D=keyword'>mesenchymal stem cells (MSCs) are plastic-adherent cells with a characteristic surface phenotype and properties of self-renewal, differentiation, and high proliferative potential. The characteristics of MSCs and their tumor-tropic capability make them an ideal tool for use in cell-based therapies for cancer, including glioma. These cells can function either through a bystander effect or as a delivery system for genes and drugs. MSCs have been demonstrated to inhibit the growth of glioma and to improve survival following transplantation into the brain. We briefly review the current data regarding the use of MSCs in the treatment of glioma and discuss the potential strategies for development of a more specific and effective therapy.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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