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CLC number: R459.9

On-line Access: 2020-08-04

Received: 2019-11-04

Revision Accepted: 2020-02-19

Crosschecked: 2020-07-20

Cited: 0

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Citations:  Bibtex RefMan EndNote GB/T7714


Xue-jun Sun


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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.8 P.593-602


Therapeutic effect of methane and its mechanism in disease treatment

Author(s):  Zhou-heng Ye, Ke Ning, Bradley P. Ander, Xue-jun Sun

Affiliation(s):  Department of Aviation and Diving Medicine, the Sixth Medical Center, General Hospital of People’s Liberation Army, Beijing 100048, China; more

Corresponding email(s):   sunxjk@126.com

Key Words:  Methane treatment, Ischemia and reperfusion injury, Inflammation, Methanogenesis

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Zhou-heng Ye, Ke Ning, Bradley P. Ander, Xue-jun Sun. Therapeutic effect of methane and its mechanism in disease treatment[J]. Journal of Zhejiang University Science B, 2020, 21(8): 593-602.

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T1 - Therapeutic effect of methane and its mechanism in disease treatment
A1 - Zhou-heng Ye
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A1 - Bradley P. Ander
A1 - Xue-jun Sun
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DOI - 10.1631/jzus.B1900629

Methane is the simplest hydrocarbon, consisting of one carbon atom and four hydrogen atoms. It is abundant in marsh gas, livestock rumination, and combustible ice. Little is known about the use of methane in human disease treatment. Current research indicates that methane is useful for treating several diseases including ischemia and reperfusion injury, and inflammatory diseases. The mechanisms underlying the protective effects of methane appear primarily to involve anti-oxidation, anti-inflammation, and anti-apoptosis. In this review, we describe the beneficial effects of methane on different diseases, summarize possible mechanisms by which methane may act in these conditions, and discuss the purpose of methane production in hypoxic conditions. Then we propose several promising directions for the future research.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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