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CLC number: R543.1

On-line Access: 2020-08-04

Received: 2020-01-16

Revision Accepted: 2020-04-20

Crosschecked: 2020-07-10

Cited: 0

Clicked: 307

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Jian-an Wang

https://orcid.org/0000-0002-4583-3204

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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.8 P.603-610

http://doi.org/10.1631/jzus.B2000022


Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models


Author(s):  Hai-qiong Zheng, Jia-bing Rong, Fei-ming Ye, Yin-chuan Xu, Hong S. Lu, Jian-an Wang

Affiliation(s):  Department of Cardiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; more

Corresponding email(s):   wangjianan111@zju.edu.cn

Key Words:  Thoracic aortic dissection (TAD), β, -Aminopropionitrile (BAPN), Angiotensin II (AngII), Mouse model, Hypertension


Hai-qiong Zheng, Jia-bing Rong, Fei-ming Ye, Yin-chuan Xu, Hong S. Lu, Jian-an Wang. Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models[J]. Journal of Zhejiang University Science B, 2020, 21(8): 603-610.

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author="Hai-qiong Zheng, Jia-bing Rong, Fei-ming Ye, Yin-chuan Xu, Hong S. Lu, Jian-an Wang",
journal="Journal of Zhejiang University Science B",
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number="8",
pages="603-610",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000022"
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%0 Journal Article
%T Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models
%A Hai-qiong Zheng
%A Jia-bing Rong
%A Fei-ming Ye
%A Yin-chuan Xu
%A Hong S. Lu
%A Jian-an Wang
%J Journal of Zhejiang University SCIENCE B
%V 21
%N 8
%P 603-610
%@ 1673-1581
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000022

TY - JOUR
T1 - Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models
A1 - Hai-qiong Zheng
A1 - Jia-bing Rong
A1 - Fei-ming Ye
A1 - Yin-chuan Xu
A1 - Hong S. Lu
A1 - Jian-an Wang
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 8
SP - 603
EP - 610
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000022


Abstract: 
thoracic aortic dissection (TAD) is one of the most lethal aortic diseases due to its acute onset, rapid progress, and high rate of aortic rupture. The pathogenesis of TAD is not completely understood. In this mini-review, we introduce three emerging experimental mouse TAD models using β;-Aminopropionitrile (BAPN) alone, BAPN for a prolonged duration (four weeks) and then with added infusion of angiotensin II (AngII), or co-administration of BAPN and AngII chronically. We aim to provide insights into appropriate application of these three mouse models, thereby enhancing the understanding of the molecular mechanisms of TAD.

β-氨基丙腈相关的小鼠胸主动脉夹层模型的综述

概要:胸主动脉夹层具有发病急、发展迅速、主动脉破裂率高的特点,是最致命的大动脉疾病之一.但是胸主动脉夹层的发病机制目前还没有被完全了解.本综述介绍了三种新兴的β-氨基丙腈相关的小鼠胸主动脉夹层模型,分别是:单用β-氨基丙腈;先用β-氨基丙腈处理(四周)再用血管紧张素2(AngII)处理;β-氨基丙腈和AngII同时进行处理.希望通过更好地运用这三种β-氨基丙腈相关的小鼠胸主动脉夹层模型,从而对胸主动脉夹层的分子机制有更深入的了解.
关键词:胸主动脉夹层;β-氨基丙腈;血管紧张素2;小鼠模型;高血压

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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