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CLC number: R543.1

On-line Access: 2020-08-04

Received: 2020-01-16

Revision Accepted: 2020-04-20

Crosschecked: 2020-07-10

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Citations:  Bibtex RefMan EndNote GB/T7714


Jian-an Wang


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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.8 P.603-610


Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models

Author(s):  Hai-qiong Zheng, Jia-bing Rong, Fei-ming Ye, Yin-chuan Xu, Hong S. Lu, Jian-an Wang

Affiliation(s):  Department of Cardiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China; more

Corresponding email(s):   wangjianan111@zju.edu.cn

Key Words:  Thoracic aortic dissection (TAD), β, -Aminopropionitrile (BAPN), Angiotensin II (AngII), Mouse model, Hypertension

Hai-qiong Zheng, Jia-bing Rong, Fei-ming Ye, Yin-chuan Xu, Hong S. Lu, Jian-an Wang. Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models[J]. Journal of Zhejiang University Science B, 2020, 21(8): 603-610.

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author="Hai-qiong Zheng, Jia-bing Rong, Fei-ming Ye, Yin-chuan Xu, Hong S. Lu, Jian-an Wang",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models
%A Hai-qiong Zheng
%A Jia-bing Rong
%A Fei-ming Ye
%A Yin-chuan Xu
%A Hong S. Lu
%A Jian-an Wang
%J Journal of Zhejiang University SCIENCE B
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%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000022

T1 - Induction of thoracic aortic dissection: a mini-review of β-aminopropionitrile-related mouse models
A1 - Hai-qiong Zheng
A1 - Jia-bing Rong
A1 - Fei-ming Ye
A1 - Yin-chuan Xu
A1 - Hong S. Lu
A1 - Jian-an Wang
J0 - Journal of Zhejiang University Science B
VL - 21
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SP - 603
EP - 610
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2000022

thoracic aortic dissection (TAD) is one of the most lethal aortic diseases due to its acute onset, rapid progress, and high rate of aortic rupture. The pathogenesis of TAD is not completely understood. In this mini-review, we introduce three emerging experimental mouse TAD models using β;-Aminopropionitrile (BAPN) alone, BAPN for a prolonged duration (four weeks) and then with added infusion of angiotensin II (AngII), or co-administration of BAPN and AngII chronically. We aim to provide insights into appropriate application of these three mouse models, thereby enhancing the understanding of the molecular mechanisms of TAD.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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