Full Text:   <28>

CLC number: 

On-line Access: 2020-12-29

Received: 2020-08-04

Revision Accepted: 2020-12-09

Crosschecked: 0000-00-00

Cited: 0

Clicked: 65

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2000431


Kidney function change after transcatheter aortic valve replacement in patients with diabetes and/or hypertension


Author(s):  Jiaqi FAN, Changjie YU, Kaida REN, Wanbing LIN, Stella NG, Zexin CHEN, Xinping LIN, Lihan WANG, Qifeng ZHU, Yuxin HE, Jubo JIANG, Xianbao LIU, Jian&rsquo,an WANG

Affiliation(s):  Department of Cardiology, Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou 310009, China; more

Corresponding email(s):   wangjianan111@zju.edu.cn, liuxb@zju.edu.cn

Key Words:  Transcatheter aortic valve replacement, Kidney function change, Diabetes mellitus, Hypertension


Jiaqi FAN, Changjie YU, Kaida REN, Wanbing LIN, Stella NG, Zexin CHEN, Xinping LIN, Lihan WANG, Qifeng ZHU, Yuxin HE, Jubo JIANG, Xianbao LIU, Jian’an WANG. Kidney function change after transcatheter aortic valve replacement in patients with diabetes and/or hypertension[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

@article{title="Kidney function change after transcatheter aortic valve replacement in patients with diabetes and/or hypertension",
author="Jiaqi FAN, Changjie YU, Kaida REN, Wanbing LIN, Stella NG, Zexin CHEN, Xinping LIN, Lihan WANG, Qifeng ZHU, Yuxin HE, Jubo JIANG, Xianbao LIU, Jian’an WANG",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000431"
}

%0 Journal Article
%T Kidney function change after transcatheter aortic valve replacement in patients with diabetes and/or hypertension
%A Jiaqi FAN
%A Changjie YU
%A Kaida REN
%A Wanbing LIN
%A Stella NG
%A Zexin CHEN
%A Xinping LIN
%A Lihan WANG
%A Qifeng ZHU
%A Yuxin HE
%A Jubo JIANG
%A Xianbao LIU
%A Jian&rsquo
%A an WANG
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000431

TY - JOUR
T1 - Kidney function change after transcatheter aortic valve replacement in patients with diabetes and/or hypertension
A1 - Jiaqi FAN
A1 - Changjie YU
A1 - Kaida REN
A1 - Wanbing LIN
A1 - Stella NG
A1 - Zexin CHEN
A1 - Xinping LIN
A1 - Lihan WANG
A1 - Qifeng ZHU
A1 - Yuxin HE
A1 - Jubo JIANG
A1 - Xianbao LIU
A1 - Jian&rsquo
A1 - an WANG
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000431


Abstract: 
The kidney function change after transcatheter aortic valve replacement (TAVR) in diabetes and/or hypertension patients is currently unknown. A total of 242 severe Aortic Stenosis patients with diabetes mellitus and/or hypertension who underwent TAVR were analyzed. Patients were categorized into 3 groups based on the percent change [(discharge eGFR – baseline eGFR) × 100/baseline eGFR] in eGFR: improved ≥ 10%, no change, and declined ≥ 10%. Of these patients, 93 (38.4%) showed an improvement in eGFR ≥ 10%, 117 (48.3%) showed no changes, and 32 (13.2%) showed a decline in eGFR of more than 10%. Patients with unchanged kidney function may be with lower STS scores (5.09 [3.58–8.34] % vs. 7.04 [4.52–9.91] % vs. 7.41 [3.52–10.97] %, p = 0.003), and lower perivascular disease (14.5% vs. 26.9% vs. 40.6%, p = 0.003) when compared with improved and declined kidney function patients, respectively. Patients with improved kidney function had lower eGFR (45.0 [33.9–60.3] mL/min/1.73m2 vs. 57.4 [43.4–70.7] mL/min/1.73m2 vs. 56.6 [44.2–76.8] mL/min/1.73m2, p = 0.000), and lower LVEF (55.1 [40.9–62.0] % vs. 60.4 [53.4–66.1] % vs. 59.9 [52.9–67.8] %, p = 0.002) than the unchanged or declined group, respectively. Moreover, patients with worsening kidney function had higher rate of in-hospital (12.5% vs. 1.7% vs. 0%, p = 0.002) and 30-day (15.6% vs. 1.7% vs. 0%, p = 0.000) mortality. Independent predictors of eGFR changes were STS scores, LVEF, baseline eGFR, and unplanned cardiopulmonary bypass. In conclusion, nearly 40% of diabetic and/or hypertensive patients experience an intermediate improvement after TAVR. Patients with declining renal function suffer more terrible outcomes in mortality.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - Journal of Zhejiang University-SCIENCE