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Sohaib Hasan Abdullah EZZI


Hui LU


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Journal of Zhejiang University SCIENCE B 2024 Vol.25 No.2 P.106-122


Recent advancements in the diagnosis and treatment of acral melanoma

Author(s):  Ahmad ALHASKAWI, Sohaib Hasan Abdullah EZZI, Yanzhao DONG, Haiying ZHOU, Zewei WANG, Jingtian LAI, Chengjun YAO, Vishnu Goutham KOTA, Mohamed Hasan Abdulla Hasan ABDULLA, Hui LU

Affiliation(s):  Department of Orthopedics, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   huilu@zju.edu.cn

Key Words:  Acral melanoma, Acral lentiginous melanoma, Acral nevus, Cutaneous malignant melanoma, Dermoscopy, Oncolytic virotherapy

Ahmad ALHASKAWI, Sohaib Hasan Abdullah EZZI, Yanzhao DONG, Haiying ZHOU, Zewei WANG, Jingtian LAI, Chengjun YAO, Vishnu Goutham KOTA, Mohamed Hasan Abdulla Hasan ABDULLA, Hui LU. Recent advancements in the diagnosis and treatment of acral melanoma[J]. Journal of Zhejiang University Science B, 2024, 25(2): 106-122.

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journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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A1 - Chengjun YAO
A1 - Vishnu Goutham KOTA
A1 - Mohamed Hasan Abdulla Hasan ABDULLA
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DOI - 10.1631/jzus.B2300221

acral melanoma (AM) is the most common histologic subtype of melanoma in dark-skinned patients and is associated with a worse prognosis and a high mortality rate, largely due to the inconspicuous nature of early-stage lesions, which can lead to late diagnosis. Because of the overlapping clinical and histopathological features of AM with other forms of cutaneous melanomas, early detection of AM requires a multidisciplinary approach that integrates various diagnostic modalities, including clinical examination, dermoscopy, histopathology, molecular testing, radiological imaging, and blood tests. While surgery is the preferred method of treatment for AM, other therapeutic options may be employed based on the stage and underlying etiology of the disease. Immune checkpoint inhibitors, molecular targeted therapy, radiotherapy, chemotherapy, and oncolytic virotherapy represent promising advanced treatment options for AM. In this review, we provide an overview of the latest advancements in diagnostic and therapeutic methods for AM, highlighting the importance of early detection and the prompt, individualized management of this challenging disease.


Ahmad ALHASKAWI1,Sohaib Hasan Abdullah EZZI2,董延钊1,周海英1,王泽伟3,来经天3,姚成俊3,Vishnu Goutham KOTA3,Mohamed Hasan Abdulla Hasan ABDULLA3,卢荟1,4


Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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