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Received: 2007-08-02

Revision Accepted: 2007-08-10

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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.9 P.609~611

10.1631/jzus.2007.B0609


Brain metastases of melanoma—mechanisms of attack on their defence system by engineered stem cells in the microenvironment


Author(s):  DIMITROV Borislav D., ATANASSOVA Penka A., RACHKOVA Mariana I.

Affiliation(s):  BORDANI, Alzano Lombardo, Bergamo 24022, Italy; more

Corresponding email(s):   bdd11@yahoo.com

Key Words:  Melanoma, Brain metastases, Neural stem/progenitor cells (NSPCs), Cytosine deaminase


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DIMITROV Borislav D., ATANASSOVA Penka A., RACHKOVA Mariana I.. Brain metastases of melanoma—mechanisms of attack on their defence system by engineered stem cells in the microenvironment[J]. Journal of Zhejiang University Science B, 2007, 8(9): 609~611.

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doi="10.1631/jzus.2007.B0609"
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T1 - Brain metastases of melanoma—mechanisms of attack on their defence system by engineered stem cells in the microenvironment
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J0 - Journal of Zhejiang University Science B
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DOI - 10.1631/jzus.2007.B0609


Abstract: 
This report gives a better emphasis on the role of targeted effectors (e.g. a combination of 5-FC with CD-NSPCs as compared to the application of NSPCs alone) and how such delivery of pro-drug activating enzymes and other tumor-killing substances may overcome melanocytic defence system, interact with and promote the host defence and immune response modulations not only in melanoma but, potentially, in other highly-metastatic cancers.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1] Aboody, K.S., Najbauer, J., Ole Schmidt, N., Yang, W., Wu, J.K., Zhuge, Y., Przylecki, W., Carroll, R., Black, P.M., Perides, G., 2006. Targeting of melanoma brain metastases using engineered neural stem/progenitor cells. Neuro-Oncology, 8(2):119-126.

[2] Altman, D.G., Bland, J.M., 1995. The normal distribution. British Medical Journal, 310:298.

[3] Dimitrov, B.D., 1993. The storage of energy as a cause of malignant transformation: a 7-phase model of carcinogenesis. Medical Hypotheses, 41(5):425-433.

[4] Dimitrov, B.D., 1997. UVR and energy storage within melanocytes: a 7-phase model of melanoma genesis and metastasis. European Journal of Dermatology, 7:461-463.

[5] Dimitrov, B.D., Rachkova, M.I., 2001. Defence Mechanisms of Melanocytes against Radiation as Based on the Rules of Non-Equilibrium Thermodynamics. In: Tenth Annual Meeting of the Pan-American Society for Pigment Cell Research. 2001 June, Minneapolis, MN, USA, p.20.

[6] Miller, R.L., Gaspari, A.A., Gillis, J.A., 2003. Method of Reducing and Treating UVB-Induced Immunosuppression. US Patent No. 7030129.

[7] Montel, V., Mose, E.S., Tarin, D., 2006. Tumor-stromal interactions reciprocally modulate gene expression patterns during carcinogenesis and metastasis. International Journal of Cancer, 119(2):251-263.

[8] Rachkova, M.I., Dimitrov, B.D., 1999. Free radical production, immunosuppression and the role of tyrosinase in melanoma genesis and metastasis. Periodicum Biologorum, 101:187-192.

[9] Raikov, Z.D., Atanasov, A.T., Raikova, E.T., 2003. Nitroxyl radicals and malignant pigment melanoma. Medical Hypotheses, 60(3):387-388.

[10] Xie, T.X., Huang, F.J., Aldape, K.D., Kang, S.H., Liu, M., Gershenwald, J.E., Xie, K., Sawaya, R., Huang, S., 2006. Activation of Stat3 in human melanoma promotes brain metastasis. Cancer Research, 66(6):3188-3196.

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