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On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Mixia WANG

https://orcid.org/0000-0002-1310-8075

Xinxia CAI

https://orcid.org/0000-0001-5997-7252

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Journal of Zhejiang University SCIENCE B 2024 Vol.25 No.10 P.803-823

http://doi.org/10.1631/jzus.B2300400


Wireless closed-loop deep brain stimulation using microelectrode array probes


Author(s):  Qianli JIA, Yaoyao LIU, Shiya LV, Yiding WANG, Peiyao JIAO, Wei XU, Zhaojie XU, Mixia WANG, Xinxia CAI

Affiliation(s):  State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, China; more

Corresponding email(s):   wangmixia@mail.ie.ac.cn, xxcai@mail.ie.ac.cn

Key Words:  Deep brain stimulation (DBS), Wireless closed-loop deep brain stimulation (CL-DBS) microsystem, Microelectrode array (MEA) probe, Optical stimulation, Electrical stimulation


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Qianli JIA, Yaoyao LIU, Shiya LV, Yiding WANG, Peiyao JIAO, Wei XU, Zhaojie XU, Mixia WANG, Xinxia CAI. Wireless closed-loop deep brain stimulation using microelectrode array probes[J]. Journal of Zhejiang University Science B, 2024, 25(10): 803-823.

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Abstract: 
deep brain stimulation (DBS), including optical stimulation and electrical stimulation, has been demonstrated considerable value in exploring pathological brain activity and developing treatments for neural disorders. Advances in DBS microsystems based on implantable microelectrode array (MEA) probes have opened up new opportunities for closed-loop DBS (CL-DBS) in situ. This technology can be used to detect damaged brain circuits and test the therapeutic potential for modulating the output of these circuits in a variety of diseases simultaneously. Despite the success and rapid utilization of MEA probe-based CL-DBS microsystems, key challenges, including excessive wired communication, need to be urgently resolved. In this review, we considered recent advances in MEA probe-based wireless CL-DBS microsystems and outlined the major issues and promising prospects in this field. This technology has the potential to offer novel therapeutic options for psychiatric disorders in the future.

基于微电极阵列探针的无线闭环脑深部刺激技术

贾千里1,2,刘瑶瑶1,2,吕诗雅1,2,王怡丁1,2,焦沛尧1,2,徐威1,2,徐兆杰1,2,王蜜霞1,2,蔡新霞1,2
1中国科学院空天信息创新研究院传感技术国家重点实验室,中国北京市,100190
2中国科学院大学电子电气与通信工程学院,中国北京市,100049
摘要:脑深部刺激(DBS),包括光刺激和电刺激,对于脑重大疾病发病机理和治疗方法开发的研究具有重要的科学意义。基于植入式微电极阵列(MEA)探针的DBS微系统的发展为原位闭环DBS(CL-DBS)提供了新机遇。闭环DBS可用于监测受损的神经细胞活动,并可根据电生理信号调整刺激参数,以实现对神经细胞活动的精准高效调控。基于MEA探针的CL-DBS微系统虽取得了快速发展,但仍有一些关键问题亟需解决,包括无线通信的安全性、稳定性和电池寿命等。本综述回顾和总结了基于MEA探针的无线CL-DBS微系统的最新进展,并探讨了该技术存在的主要问题和未来发展前景。未来,基于MEA探针的无线CL-DBS技术的不断发展和进步将继续为神经科学和临床神经学带来创新,并为脑重大疾病的治疗提供新策略。

关键词:脑深部刺激(DBS);无线闭环脑深部刺激微系统;微电极阵列探针;光刺激;电刺激

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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