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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2300566


EVs’ journey in recipient cells: from recognition to cargo release


Author(s):  Huayuan XIANG, Chenxuan BAO, Qiaoqiao CHEN, Qing GAO, Nan WANG, Qianqian GAO, Lingxiang MAO

Affiliation(s):  Department of Laboratory Medicine, Affiliated Kunshan Hospital of Jiangsu University, Suzhou, Jiangsu, China

Corresponding email(s):   maolingxiang@aliyun.com

Key Words:  Extracellular vesicles (EVs), Exosomes, Endocytosis, Uptake, Release


Huayuan XIANG, Chenxuan BAO, Qiaoqiao CHEN, Qing GAO, Nan WANG, Qianqian GAO, Lingxiang MAO. EVs’ journey in recipient cells: from recognition to cargo release[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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Abstract: 
extracellular vesicles (EVs) are nano-sized bilayer vesicles that are shed or secreted by virtually every cell type. A variety of biomolecules, including proteins, lipids, coding and non-coding RNAs, mitochondrial DNA, and so on, can be selectively encapsulated into EVs and delivered to nearby and distant recipient cells, leading to alterations in the recipient cells, suggesting that EVs play an important role in intercellular communication. EVs play effective roles in physiology and pathology and could be used as diagnostic and therapeutic tools. At present, although the mechanisms of exosome biogenesis and secretion in donor cells are well understood, the molecular mechanism of EVs recognition and uptake by recipient cells is still unclear. This review summarizes the current understanding of the molecular mechanisms of EVs’ biological journey in recipient cells, from recognition to uptake and cargo release. Furthermore, we highlight how EVs escape endolysosomal degradation after uptake and thus release cargo, which is crucial for studies applying EVs as drug-targeted delivery vehicles. Knowledge of the cellular processes that govern extracellular vesicle uptake is important to shed light on the functions of EVs as well as on related clinical applications.

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