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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2300614


Advancements in molecular imaging probes for precision diagnosis and treatment of prostate cancer


Author(s):  Jiajie FANG, Ahmad ALHASKAWI, Yanzhao DONG, Cheng CHENG, Zhijie XU, Junjie TIAN, Sahar Ahmed ABDALBARY, Hui LU

Affiliation(s):  Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310024, China; more

Corresponding email(s):   huilu@zju.edu.cn

Key Words:  Molecular imaging, Prostate cancer, Nuclear medicine, PSMA, Nanoparticle


Jiajie FANG, Ahmad ALHASKAWI, Yanzhao DONG, Cheng CHENG, Zhijie XU, Junjie TIAN, Sahar Ahmed ABDALBARY, Hui LU. Advancements in molecular imaging probes for precision diagnosis and treatment of prostate cancer[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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Abstract: 
prostate cancer is the second most common cancer in men, accounting for 14.1% of new cancer cases in 2020. The aggressiveness of prostate cancer is highly variable, depending on its grade and stage at the time of diagnosis. Despite recent advances in prostate cancer treatment, some patients still experience recurrence or even progression after undergoing radical treatment. Accurate initial staging and monitoring for recurrence determines patient management, which in turn affects patient prognosis and survival. Classical imaging has limitations in the diagnosis and treatment of prostate cancer, but the use of novel molecular probes has improved the detection rate, specificity, and accuracy of prostate cancer detection. Molecular probe-based imaging modalities allow the visualization and quantitative measurement of biological processes at the molecular and cellular levels in living systems. An increased understanding of tumor biology of prostate cancer and the discovery of new tumor biomarkers have allowed the exploration of additional molecular probe targets. The development of novel ligands and advances in nano-based delivery technologies have accelerated the research and development of molecular probes. Here, we summarize the use of molecular probes in PET, SPECT, MRI, optical imaging, and ultrasound imaging, and provide a brief overview of important target molecules in prostate cancer.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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