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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2300767


Effects of glyphosate, antibiotics and an anticoccidial drug on pancreatic gene expression and blood physiology in broilers


Author(s):  Georgi Yu. LAPTEV, Daria G. TIURINA, Elena A. YILDIRIM, Elena P. GORFUNKEL, Larisa A. ILINA, Valentina A. FILIPPOVA, Andrei V. DUBROVIN, Alisa S. DUBROVINA, Evgeni A. BRAZHNIK, Natalia I. NOVIKOVA, Veronika Kh. MELIKIDI, Kseniya A. KALITKINA, Ekaterina S. PONOMAREVA, Vasiliy A. ZAIKIN, Darren K. GRIFFIN, Michael N. ROMANOV

Affiliation(s):  BIOTROF+ Ltd, Pushkin, St. Petersburg, 196602, Russia; more

Corresponding email(s):   deniz@biotrof.ru, m.romanov@kent.ac.uk

Key Words:  Glyphosate, Antibiotics, Anticoccidial drug, Pancreas, broilers, Gene expression, Blood indices


Georgi Yu. LAPTEV, Daria G. TIURINA, Elena A. YILDIRIM, Elena P. GORFUNKEL, Larisa A. ILINA, Valentina A. FILIPPOVA, Andrei V. DUBROVIN, Alisa S. DUBROVINA, Evgeni A. BRAZHNIK, Natalia I. NOVIKOVA, Veronika Kh. MELIKIDI, Kseniya A. KALITKINA, Ekaterina S. PONOMAREVA, Vasiliy A. ZAIKIN, Darren K. GRIFFIN, Michael N. ROMANOV. Effects of glyphosate, antibiotics and an anticoccidial drug on pancreatic gene expression and blood physiology in broilers[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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author="Georgi Yu. LAPTEV, Daria G. TIURINA, Elena A. YILDIRIM, Elena P. GORFUNKEL, Larisa A. ILINA, Valentina A. FILIPPOVA, Andrei V. DUBROVIN, Alisa S. DUBROVINA, Evgeni A. BRAZHNIK, Natalia I. NOVIKOVA, Veronika Kh. MELIKIDI, Kseniya A. KALITKINA, Ekaterina S. PONOMAREVA, Vasiliy A. ZAIKIN, Darren K. GRIFFIN, Michael N. ROMANOV",
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%T Effects of glyphosate, antibiotics and an anticoccidial drug on pancreatic gene expression and blood physiology in broilers
%A Georgi Yu. LAPTEV
%A Daria G. TIURINA
%A Elena A. YILDIRIM
%A Elena P. GORFUNKEL
%A Larisa A. ILINA
%A Valentina A. FILIPPOVA
%A Andrei V. DUBROVIN
%A Alisa S. DUBROVINA
%A Evgeni A. BRAZHNIK
%A Natalia I. NOVIKOVA
%A Veronika Kh. MELIKIDI
%A Kseniya A. KALITKINA
%A Ekaterina S. PONOMAREVA
%A Vasiliy A. ZAIKIN
%A Darren K. GRIFFIN
%A Michael N. ROMANOV
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
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%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
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A1 - Elena P. GORFUNKEL
A1 - Larisa A. ILINA
A1 - Valentina A. FILIPPOVA
A1 - Andrei V. DUBROVIN
A1 - Alisa S. DUBROVINA
A1 - Evgeni A. BRAZHNIK
A1 - Natalia I. NOVIKOVA
A1 - Veronika Kh. MELIKIDI
A1 - Kseniya A. KALITKINA
A1 - Ekaterina S. PONOMAREVA
A1 - Vasiliy A. ZAIKIN
A1 - Darren K. GRIFFIN
A1 - Michael N. ROMANOV
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
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Y1 - 1998
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2300767


Abstract: 
Drugs and pesticide residues in broiler feed can compromise the therapeutic and production benefits of antibiotic application and affect gene expression. In this study, we analyzed the expression of 13 key pancreatic genes and blood physiology parameters after administering the following: one maximum residue limit of herbicide glyphosate (GLY), two antibiotics (ANT), and one anticoccidial drug (AD). A total of 260 Ross 308 broilers aged 1 to 40 days were divided into the following four groups of 65 birds each: (1) control group fed the main diet (MD), and three experimental groups fed MD supplemented with (2) GLY, (3) GLY+ANT (enrofloxacin and colistin methanesulfonate) and (4) GLY+AD (ammonium maduramicin). The results showed that the addition of GLY, GLY+ANT and GLY+AD caused significant changes in the expression of several genes of physiological and economic importance. In particular, genes related to inflammation and apoptosis (IL6, PTGS2 and CASP6) were downregulated by up to 115.4 times, and those related to antioxidant protection (CAT, SOD1 and PRDX6) by up to 69.4 times, compared to controls. There was also a significant decline in the values of immunological characteristics in the blood serum observed in the experimental groups and certain changes in gene expression were concordant with changes in the functioning of the pancreas and blood. The changes revealed in gene expression and levels of blood indices in response to GLY, ANT and AD provide insights into the possible mechanisms of action of these agents at the molecular level. Specifically, these changes may be indicative of physiological mechanisms to overcome the negative effects of GLY, GLY+ANT and GLY+AD in broilers.

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