Full Text:
<323>
CLC number:
On-line Access: 2023-05-15
Received: 2023-03-16
Revision Accepted: 2023-05-08
Crosschecked: 0000-00-00
Cited: 0
Clicked: 475
Cellulose nanofibril matrix drives the dynamic formation of spheroids
| |||||||||||||
Yi LU, Guo LI, Yeqiu LI, Yuan YAO. Cellulose nanofibril matrix drives the dynamic formation of spheroids[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Cellulose nanofibril matrix drives the dynamic formation of spheroids",
author="Yi LU, Guo LI, Yeqiu LI, Yuan YAO",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B23Z0003"
}
%0 Journal Article
%T Cellulose nanofibril matrix drives the dynamic formation of spheroids
%A Yi LU
%A Guo LI
%A Yeqiu LI
%A Yuan YAO
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B23Z0003
TY - JOUR
T1 - Cellulose nanofibril matrix drives the dynamic formation of spheroids
A1 - Yi LU
A1 - Guo LI
A1 - Yeqiu LI
A1 - Yuan YAO
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B23Z0003
Abstract: Multicellular spheroids, which mimic the natural organ counterparts, allow the prospect of drug screening and regenerative medicine. However, their application is hampered by low processing efficiency or limited scale. This study introduces an efficient method to drive rapid multicellular spheroid formation by a cellulose nanofibril matrix. This matrix enables the facilitated growth of spheroids (within 48 hours) through multiple cell assembly into size-controllable aggregates with well-organized physiological microstructure. The efficiency, dimension, and conformation of the as-formed spheroids depend on the concentration of extracellular nanofibrils, the number of assembled cells, and the heterogeneity of cell types. The above strategy allows the robust formation mechanism of compacted tumoroids and hepatocyte spheroids.
Open peer comments: Debate/Discuss/Question/Opinion
<1>